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EC number: 220-971-6 | CAS number: 2950-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
Data available for the structurally similar and closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8). The studies are as mentioned below:
1. Acute oral toxicity study of test chemical was conducted in rat at the concentration of 2000 mg/kg bw. 50% mortality was observed at 2000 mg/kg bw. Therefore, LD50 was considered to be 2000 mg/kg bw, when rats were treated with test chemical via oral route.
2. Acute oral toxicity study of test chemical was conducted in mice at the concentration of 1100 mg/kg bw. 50% mortality was observed at 1100 mg/kg bw. Therefore, LD50 was considered to be 1100 mg/kg bw, when mice were treated with test chemical via oral route.
Thus, based on the above summarised studies, Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) and it’s structurally similar and closely related read across substances, it can be concluded that LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) can be classified as “Category 4” for acute oral toxicity. Hence, Hydroxylamine-O-sulphonic acid is toxic for acute oral toxicity at the dose range of 1100-2000 mg/kg bw.
Acute Inhalation toxicity:
Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) has very low vapour pressure (1.52E-14 Pa), so the potential for the generation of inhalable vapours is very low. Also the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore this end point was considered for waiver.
Acute Dermal Toxicity:
The study need not be conducted because the substance is a strong acid (pH<=2.0). The experimental pH of Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) was 1.81. Hence this endpoint was considered for waiver.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar and closely related read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is based on 2 acute oral toxicity studies as- WoE-2 and WoE-3.
Acute Oral toxicity test was carried out to study the effects of the test chemicals on rodents. - GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- Name: Hydroxylamine-O-sulphonic acid
InChI: 1S/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4)
Smiles: O=S(=O)(ON)O
Mol. formula: H3NO4S
Molecular Weight: 113.093 g/mole
Substance Type: Inorganic - Species:
- other: 1. rat 2. mouse
- Strain:
- other: 1. not specified 2. not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 1. not specified
2. not specified - Route of administration:
- other: 1. oral: unspecified 2. oral: unspecified
- Vehicle:
- other: 1. not specified 2. not specified
- Details on oral exposure:
- 1. not specified
2. not specified - Doses:
- 1. 2000 mg/kg
2. 1100 mg/kg - No. of animals per sex per dose:
- 1. not specified
2. not specified - Control animals:
- not specified
- Details on study design:
- 1. not specified
2. not specified - Statistics:
- 1. not specified
2. not specified - Preliminary study:
- 1. not specified
2. not specified - Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 1. 50% mortality was observed at 2000 mg/kg
2. 50% mortality was observed at 1100 mg/kg - Clinical signs:
- other: 1. not specified 2. not specified
- Gross pathology:
- 1. not specified
2. not specified - Other findings:
- 1. not specified
2. not specified - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- According to CLP regulation the test chemical Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) can be classified as "Category 4 " for acute oral toxicity, as the LD50 value is between 300-2000 mg/kg bw.
- Executive summary:
Data available for the structurally similar and closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8). The studies are as mentioned below:
1. Acute oral toxicity study of test chemical was conducted in rat at the concentration of 2000 mg/kg bw. 50% mortality was observed at 2000 mg/kg bw. Therefore, LD50 was considered to be 2000 mg/kg bw, when rats were treated with test chemical via oral route.
2. Acute oral toxicity study of test chemical was conducted in mice at the concentration of 1100 mg/kg bw. 50% mortality was observed at 1100 mg/kg bw. Therefore, LD50 was considered to be 1100 mg/kg bw, when mice were treated with test chemical via oral route.
Thus, based on the above summarised studies, Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) and it’s structurally similar and closely related read across substances, it can be concluded that LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) can be classified as “Category 4” for acute oral toxicity. Hence, Hydroxylamine-O-sulphonic acid is toxic for acute oral toxicity at the dose range of 1100-2000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from handbook.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Quality of whole database:
- Waiver
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
Reference
Endpoint conclusion
- Quality of whole database:
- Waiver
Additional information
Acute oral toxicity:
Data available for the structurally similar and closely related read across chemicals has been reviewed to determine the acute oral toxicity of the test chemical Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8). The studies are as mentioned below:
1. Acute oral toxicity study of test chemical was conducted in rat at the concentration of 2000 mg/kg bw. 50% mortality was observed at 2000 mg/kg bw. Therefore, LD50 was considered to be 2000 mg/kg bw, when rats were treated with test chemical via oral route.
2. Acute oral toxicity study of test chemical was conducted in mice at the concentration of 1100 mg/kg bw. 50% mortality was observed at 1100 mg/kg bw. Therefore, LD50 was considered to be 1100 mg/kg bw, when mice were treated with test chemical via oral route.
Thus, based on the above summarised studies, Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) and it’s structurally similar and closely related read across substances, it can be concluded that LD50 value is between 300-2000 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation, Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) can be classified as “Category 4” for acute oral toxicity. Hence, Hydroxylamine-O-sulphonic acid is toxic for acute oral toxicity at the dose range of 1100-2000 mg/kg bw.
Acute Inhalation toxicity:
Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) has very low vapour pressure (1.52E-14 Pa), so the potential for the generation of inhalable vapours is very low. Also the normal conditions of use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be highly unlikely and therefore this end point was considered for waiver.
Acute Dermal Toxicity:
The study need not be conducted because the substance is a strong acid (pH<=2.0). The experimental pH of Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) was 1.81. Hence this endpoint was considered for waiver.
Justification for classification or non-classification
Based on the above studies on Hydroxylamine-O-sulphonic acid (CAS no.: 2950-43-8) and it’s structurally similar and closely related read across substances, it can be concluded that LD50 value is between 300-2000 mg/kg bw, for acute oral toxicity. Thus, comparing this value with the criteria of CLP regulation, Hydroxylamine-O-sulphonic acid can be classified as “Category 4” for acute oral toxicity. For acute inhalation and dermal toxicity wavier were added so, not possible to classify.
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