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EC number: 441-000-4 | CAS number: 121219-07-6 1-ETHOXY-2,3-DIFLUORBENZOL; 1-ETHOXY-2,3-DIFLUOROBENZENE; 2,3-DIFLUOROPHENETOL; DIPHOL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 96/54/EG, B.7; OECD 407 (1995)
- GLP compliance:
- yes
- Limit test:
- no
Test animals
- Species:
- other: rat, HanIbm:WIST (SPF)
Administration / exposure
- Vehicle:
- other: Miglyol 812 Neutralöl
- Details on exposure:
- Method of administration:
gavage - Duration of treatment / exposure:
- Test duration: 28 days
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 100 mg/kg bw/day
Male: 5 animals at 300 mg/kg bw/day
Male: 10 animals at 1000 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 100 mg/kg bw/day
Female: 5 animals at 300 mg/kg bw/day
Female: 10 animals at 1000 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
One female treated with 1000 mg/kg/d was found dead on Day
16. Animals of this dose group showed treatment-related
clinical symptoms such as piloerection, increased
salivation, hunched posture (females only) and dyspnoea and,
possibly attributed to the bad taste of the test substance,
increased incidence of coprophagia and bedding consumption.
Neurofunctional testing battery revealed reduced mean
locomotor activity of animals treated with 1000 mg/kg/d.
During the first week of treatment period, the food
consumption was nonsignificantly lower in animals at this
dosage compared to the control values. The mean body weights
and body weight gain of males treated with 1000 mg/kg/d were
reduced during the treatment period (nonsignificantly) and
remained lower during the recovery phase (significantly).
Laboratory findings:
Males and females treated with 1000 mg/kg/d had increased
levels of total cholesterol, triglycerides and phospholipids
and increased activity of ALAT. Slightly higher globulin
levels were noted in females treated with 1000 mg/kg/d, and
the albumin/globulin ratio was slightly lower.
Urinalysis revealed incrased specific gravity of urine of
animals of the group that received 1000 mg/kg/d.
Effects in organs:
Treatment-related organ weigth changes were confined to
increased liver weights in males and females at 1000 mg/kg/d
at the end of study, that were reversible until the end of
the recovery period.
No treatment-related macroscopic findings were found,
microscopic lesions contributed to the test substance were
minimal to slight hepatocellular hypertrophy in central and
intermediate zones of the liver lobules; This effect has
been observed in males of all dose groups and in females of
the high dose group; its incidences increased with dosage.
After recovery, it decreased in severity and incidence, but
was still apparent at the end of this period.
The course of death of the spontaneously dying high dose
females could not be established.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 100.3 mg/kg bw/day
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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