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Diss Factsheets
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EC number: 268-974-1 | CAS number: 68155-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February from 21st to 27th, 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted May 12, 1981
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reactive Yellow 125
- IUPAC Name:
- Reactive Yellow 125
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, CH 4414 Fuellinsdorf / Switzerland.
- Age at study initiation: 15 - 16 weeks.
- Weight at study initiation: 2.3 - 2.5 kg
- Acclimation period: 3 days.
Test system
- Type of coverage:
- not specified
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Observation period:
- 72 hours
- Number of animals:
- 1 male and 1 female
- Details on study design:
- OBSERVATION TIME POINTS
1, 24, 48 and 72 hours.
SCORING SYSTEM
ERYTHEMA AND ESCHAR FORMATION
No enythema 0
Very slight enythema (barely perceptible) 1
Well defined enythema 2
Moderate to severe enythema 3
Sevene erythema (beet redness) to slight eschar formation (injuries in depth) 4
OEDEMA FORMATION
No edema 0
Veny sIight edema (barely perceptible) 1
Slight edema (edges of area weIl defined by definite raising) 2
Moderate edema (raised approximately 1 mm) 3
Sevene edema (raised more than 1 mm and extending beyond area of exposure) 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 2/2
- Time point:
- 24/48/72 h
- Score:
- < 2.3
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: 2/2
- Time point:
- 24/48/72 h
- Score:
- < 2.3
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Under the conditions of the experiment, test item was found to cause a primary irritation score of 0 when applied to intact rabbit skin. In the area of application, a hardly perceptible yeIlow discolouration of the skin was observed, which could be related to effects of the test article.
No corrosion effect has occurred on the skin at each measuring interval.
Any other information on results incl. tables
Animal N. | Reaction | 1 hr | 24 hrs | 48 hrs | 72 hrs |
29 M | Erythema | 0 | 0 | 0 | 0 |
30 F | Erythema | 0 | 0 | 0 | 0 |
29 M | Oedema | 0 | 0 | 0 | 0 |
30 F | Oedema | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified, according to the CLP Regulation (EC) 1272/2008
- Conclusions:
- Not skin irritating
- Executive summary:
The primary skin irritation potential of the substance was investigated according to OECD test guideline no. 404. The test item was moinstened with tap water, to one male and one female New Zealand White rabbits. The scoring of skin reactions was performed 1, 24, 48 and 72 hours.
Under the conditions of the experiment, test item was found to cause a primary irritation score of 0 when applied to intact rabbit skin. In the area of application, a hardly perceptible yeIlow discolouration of the skin was observed, which could be related to effects of the test article.
No corrosion effect has occurred on the skin at each measuring interval.
Conclusion
Mean values from gradings at 24, 48 and 72 hours were lower than 2.3 in all animals for both erythema/eschar and oedema reactions. Although two animals, instead of three, the results can be considered as sufficiently clear and probative to conclude that the test item does not meet the criteria to be classified as irritating, according to the CLP Regulation (EC) No 1272/2008.
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