Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 821-762-8 | CAS number: 4563-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Name:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Type of composition:
- boundary composition of the substance
- State / form:
- liquid
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- Reference substance:
- Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The PBT Assessment for the substance is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2014).
Persistency
One experimental study is available investigating the biodegradability of the substance. The study was performed according to EU Method C.6 (similar to OECD 301D). After 27 d the substance was degraded to < 5% indicating that the substance is not readily biodegradable according to the OECD criteria. Thus, the substance is considered to be potentially P/vP based on the available data.Bioaccumulation
In accordance with ECHA Guidance R.11 (ECHA, 2017) the substance is not considered to meet the screening criterion for B assessment in aquatic species. Monomeric or dimeric neutral forms together with the basic form are presented in phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts. The log Pow of the neutral forms is with 3.4 below the trigger value of 4.5. With a molecular weight > 3000 it is unlikely that the basic form of the substance is bioavailable. Therefore the log Pow for the neutral form is used as key value for the chemical safety assessment.However, according to ECHA Guidance R.11 (ECHA, 2017) there is indication that accumulation in air breathing organisms might occur based on the calculated log Koa of 8.37 (calculated with KOAWIN v.1.10 using the Henry's law constant of 0.0266 Pa m³/mol and the Log Pow of 3.4 as input parameters) in combination with the log Pow > 2. These screening values (Kow and Koa) referred to in the ECHA Guidance R.11 are a function of the modelled organisms, food webs and environments used to obtain these values. To develop this partition coefficient combination it was clearly indicated in the guidance that biomagnification potential is only assumed for substances with high chemical absorption efficiency from the diet, no biotransformation after absorption and negligible active transport (in or out).
The evaluation of the toxicokinetic behavior indicates that due to a high molecular weight (>=996.9 <=3072-09) absorption is expected to be low. However relatively low effects were observed in the oral acute toxicity test toward rats treated with the source substance which indicated either low amount of test material was absorbed, and/or the test material has low inherent toxicity. Due to the high molecular weight a dermal adsorption is predicted to be very low. Based on the very low vapor pressure, the volatility is low and hence, the potential for absorption via inhalation is considered to be negligible. Overall a systematic bioavailability of the target and source substances in humans is considered possible but limited after oral uptake of the substance due to their high molecular weights, which is also supported by the available acute and repeated dose toxicity data.
However, there is evidence for biotransformation and active transport of the substance after uptake. The potential metabolites following enzymatic metabolism were predicted using the QSAR OECD toolbox (v4.1, OECD, 2017). The QSAR tool predicts which metabolites may result from enzymatic activity in the liver and in the skin, and by intestinal bacteria in the gastrointestinal tract. 8 hepatic and 2 dermal metabolites were predicted for the target substance, respectively. The results of the OECD Toolbox prediction substantiate the information on metabolism known from general literature (Lehninger, 1993). Primarily, the formation of mono esters with phosphorothioic acid and the formation of dodecanol by hydrolysis of the parent substance are the predicted metabolites which may occur in the liver. In the skin, hydrolysis of the terminal methyl group of the aliphatic side chain was predicted. Besides the predicted liver and skin metabolites, up to 102 metabolites for the target substance and 34 metabolites for the source substance were predicted to result from all kinds of microbiological metabolism for the test substance. Most of the metabolites were found to be a consequence of the degradation of the molecule. The formation of CO2 as metabolite is also predicted, which will be excreted via exhaled air. For further details on the toxicokinetic behavior please refer to the toxicokinetic statement in IUCLID section 7.1.
Reliable QSAR models (BCFBAF Program v3.01) incorporated in the EPI Suite v4.1 interphase, were additional used to calculate the bioconcentration factors (BCF) of the substance. A BCF value of 81.34 L/ Kg wet-wet was predicted by the regression based model (Meylan, 1997) while a BCF of 0.5958 Bio Half-life (days) was estimated by the Arnot and Gobas model (2003) taking biotransformation into account these results show a low bioaccumulation potential of the substance and support the toxicocinetics outcome concerning a high rate of biotransformation after uptake. In conclusion, the trigger values for biomagnification in air-breathing (terrestrial) organisms as stipulated in the ECHA Guidance R.11 are likely to overestimate the potential for biomagnification in the food chain.
Even though absorption via oral exposure cannot be completely excluded the described metabolic and excretion pathways are likely to minimize biomagnification in the food chain.
Based on the information above it can be concluded that the substance is considered to be not B/vB based on the available data.
Toxicity
Available data on aquatic long-term toxicity are clearly ≥ 0.01 mg/L (NOELR (72 h): 220 mg/L). Moreover, the test substance is not classified for toxicity according to the criteria in Annex XIII of Regulation (EC) No 1907/2006 based on Regulation (EC) No 1272/2008. Thus, the criteria set out in Annex XIII of Regulation (EC) No 1907/2006 are not met and the test substance is not considered to meet the T criterion.In conclusion, the substance is not PBT/vPvB.
Referenceopen allclose all
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.