Registration Dossier
Registration Dossier
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EC number: 201-803-0 | CAS number: 88-14-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute dermal toxicity study of test chemical on rabbits
- Author:
- D. L. J. Opdyke
- Year:
- 1 973
- Bibliographic source:
- Food and Cosmetics Toxicology, 1973
- Reference Type:
- other: Authoritative database
- Title:
- Acute dermal toxicity of test chemical on rabbits
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Determination of acute dermal toxicity of the test chemical on rabbits
- GLP compliance:
- not specified
- Test type:
- other: Not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzyl formate
- EC Number:
- 203-214-4
- EC Name:
- Benzyl formate
- Cas Number:
- 104-57-4
- Molecular formula:
- C8H8O2
- IUPAC Name:
- Benzyl formate
- Test material form:
- liquid
- Details on test material:
- IUPAC name: Benzyl formate
Mol. formula: C8H8O2
Molecular Weight:136.149 gm/mol
Smiles: c1(ccccc1)COC=O
InChI: 1S/C8H8O2/c9-7-10-6-8-4-2-1-3-5-8/h1-5,7H,6H2
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 1.3-3.0 ml/kg (1300-3000 mg/kg)
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The dermal LD50 value was observed to be 2000 mg/kg when rabbits were treated with test chemical.
- Executive summary:
The acute dermal toxicity study was conducted on rabbits for 14 days period. 50% mortality was observed at a dose level of 2000 mg/kg. Thus, based on the LD50 value, the test chemical cannot be classified as per the CLP regulation.
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