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EC number: 222-226-0 | CAS number: 3391-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 15 August 2017 and 17 August 2017 (biological phase).
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Oct-1-ene-3-ol
- EC Number:
- 222-226-0
- EC Name:
- Oct-1-ene-3-ol
- Cas Number:
- 3391-86-4
- Molecular formula:
- C8H16O
- IUPAC Name:
- oct-1-en-3-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Batch No.: VE00440179
Colour and Appearance: colourless to pale yellow liquid
Purity: 99.6%
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples of stock solution and test solutions were taken to determine the actual test item concentrations in comparison to the nominally applied concentrations. Samples of test solutions were taken at the start of exposure in the fresh test solution (0 hour) and in the aged test solution (48h)
Test solutions
- Vehicle:
- no
- Details on test solutions:
- A stock solution (S1) of the test item was prepared by dissolving 0.1003 g of the test item in 1000 mL of test medium, resulting in a nominal concentration of 100 mg/L. This stock solution was stirred for 1-h at ambient temperature in the dark. Subsequent inspection of the solution showed no undissolved matter. The stock solution was used immediately to prepare the desired test item concentrations. The stock solution was used, undiluted, as the highest test concentration. The diluted test solutions were stirred for another 10 min.
Frequency and Duration of Administration, Treatment Levels, and Replication
Based on the results of a preliminary non-GLP range finding test, the following concentrations in a geometrical series (spacing factor: 1.77) were tested in the definitive test: 10.2, 18.0, 31.9, 56.5 and 100 mg test item/L. The test period (exposure of test organisms to the test solutions in a static system) was 48 hours. Additionally, daphnids were exposed under control conditions (non-treated test medium without solvent).
Four replicates were used for the test item concentrations and the control. Each replicate vessel contained five daphnids.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test System
• Species: The test system used in this study was Daphnia magna STRAUS (clone M10), a water flea, cultured at ECT Oekotoxikologie GmbH since December 22, 2011.
• Origin: The organisms were originally supplied by KU Leuven, Belgium.
The health of the Daphnia culture and the overall quality of the test organisms is monitored regularly by using the reference toxicant potassium dichromate (K2Cr2O7) in an acute test design in order to determine the sensitivity of the organisms from the culture and to demonstrate that the test conditions are appropriate.
The most recent reference test with potassium dichromate performed in a separate study (Study No. IDA1705) resulted in an EC50(24 h) of 1.29 mg/L.
According to the OECD guideline No. 202 (OECD, April 2004) EC50(24 h)-values for potassium dichromate obtained from different laboratories should range between 0.6 mg/l and 2.1 mg/l. The toxicity of the reference item is within this range. Therefore the results of this reference test are acceptable and the test conditions are reliable and the sensitivity of the test system could be demonstrated.
Study design
- Test type:
- static
- Water media type:
- other: Elendt medium M4 was used to dilute the test item and to keep the daphnids during the period of the test.
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19.7 - 20.9 °C
- pH:
- 7.7 - 7.8
- Nominal and measured concentrations:
- Nominal: 10.2, 18.0, 31.9, 56.5 and 100 mg test item/L.
Geometric mean: 3.67, 8.61, 24.04, 43.26, 48.72 mg test item/L.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.02 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CI: 6.27 to 10.29 mg/L
- Duration:
- 48 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- 5.13 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 4.07 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Biological results: The % immobility reflected the concentration series. At 48h the percentage of immobilised daphnids was 0% (control), 10% (10.2mg/L nominal), 50% (18mg/L nominal) and 100% (31.9, 56.5 and 100mg/L nominal). Sublethal observations on the mobile daphnids were recorded. At 10.2, 18.0, 31.9 and 56.5 mg/L after 24 h and at 10.2 and 18.0 mg/L after 48 h, an increasing number of floaters and reduced swimming activity were observed.
Analytical Results: The measured concentrations in the test solutions at the start of exposure (0h) ranged from 25 to 83% of the nominal concentration and at the end of exposure (48h) from 34-84% of nominal. Given that the measured concentrations were not within 80% of the nominal concentrations, the biological endpoints reported are based on the geometric mean measured concentrations. The latter were calculated to be 3.67, 8.81, 24.04, 43.26 and 48.72 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the statistical evaluation of biological results and geometric measured concentrations of the test item, the 48-hour EC50 for Daphnia magna was 8.02 mg/L (95% confidence limits: 6.27 - 10.29 mg/L).
- Executive summary:
The acute toxicity of the test item Amyl Vinyl Carbinol to Daphnia magna was determined in a 48-hour test according to the OECD Guideline for Testing of Chemicals, No. 202 (2004) and the Commission Regulation (EC) No. 440/2008, Part C.2.
Based on the statistical evaluation of biological results and geometric measured concentrations of the test item, the 48-hour EC50 for Daphnia magna was 8.02 mg/L (95% confidence limits: 6.27 - 10.29 mg/L).
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