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Diss Factsheets
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EC number: 219-529-5 | CAS number: 2455-24-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines/standards. No GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM Comitee E-35 (Standard practice for conducting acute toxicity tests with fishes, macroinvertbrates and amphibians. 1980)
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- no data
- Vehicle:
- no
- Details on test solutions:
- no data
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead Minnow
- Age at study initiation (mean and range, SD): 28 to 34 days
- Length at study initiation (length definition, mean, range and SD): 20.9 ± 2.0 mm
- Weight at study initiation (mean and range, SD): 0.134 ± 0.34 g
- Feeding during test no data
ACCLIMATION
no data - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no
- Hardness:
- 45.3 ± 1.0 mg/L as CaCO3
- Test temperature:
- 24.6 ± 0.4 °C
- pH:
- 7.62 ± 0.12
- Dissolved oxygen:
- 6.71 ± 0.57 mg/L
- Salinity:
- no data
- Nominal and measured concentrations:
- tested concentrations not specified in the publication
- Details on test conditions:
- TEST SYSTEM
- Test vessel: continuous flow modified Benoit mini-diluter system
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): no data
- No. of organisms per vessel: no data
- No. of vessels per concentration (replicates): no data
- Biomass loading rate: no data
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Lake Superior Water, filtered through a sand/gravel filter
OTHER TEST CONDITIONS
- Adjustment of pH: no data
- Photoperiod: 16 h light/ 8 h dark
- Light intensity: no data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
daily observation: abnormal behavioural and morphological changes
TEST CONCENTRATIONS
no data - Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 34.7 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 60.9 mg/L
- Remarks on result:
- other: QSAR calculation
- Details on results:
- - Behavioural abnormalities: reduced spontaneous locomotor activity
- no permanent deformities
- probable MoA: narcosis - Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 96 h-LC50 of THFMA in Pimephales promelas (Fathead Minnow) is reported to be 34.7 mg/L.
- Executive summary:
In a 96-h acute toxicity study according to ASTM guideline "Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians" (1980), Pimephales promelas (Fathead Minnow) were exposed to THFMA (>97%) under flow through conditions. The concentrations tested were not specified in this publication.
The 96-h LC50 was 34.7 mg/L.
Reduced spontaneous locomotor activity associated with a narcotic mode of action, but no permanent deformities were observed.
Results Synopsis
Test organism size/age (mean wet weight or length): Pimephales promelas, 28 – 34 days, 20.9 ± 2.0 mm
Test Type: Flowthrough
LC50: 34.7 mg/L
Endpoint(s) Effected: mortality
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Description of key information
LC50=34.7 mg/L; ASTM guideline "Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians” (flow through); no GLP
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 34.7 mg/L
Additional information
One study on acute toxicity of THFMA to fish is available, which is considered as reliable with restrictions (RL=2):
In a 96-h acute toxicity study according to ASTM guideline "Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians" (1980), Pimephales promelas (Fathead Minnow) were exposed to THFMA (>97%) under flow through conditions. The concentrations tested were not specified in this publication.Reduced spontaneous locomotor activity associated with a narcotic mode of action, but no permanent deformities were observed.
The 96-h LC50 was 34.7 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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