Sodium metaphosphate

Endpoint summary

Description of key information

Skin irritation supporting studies:

1.Sodium Hexametaphosphate (concentration not specifed) had the maximum primary irritation index (PII) score of 8.0 in the standard Draize dermal irritation assay using six rabbits. All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.

2. Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant) in the standard Draize dermal irritation assay using six rabbits.

Eye irritation supporting studies:

Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Reference 1

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

A scientific review, data insufficient for assesment.

Principles of method if other than guideline:

Standard Draize dermal irritation assay.

GLP compliance:

not specified

Species:

rabbit

Strain:

not specified

Remarks on result:

other: All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours

All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.

Interpretation of results:

study cannot be used for classification

Conclusions:

All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.

Executive summary:

Sodium Hexametaphosphate (concentration not specifed) had the maximum primary irritation index (PII) score of 8.0 in the standard Draize dermal irritation assay using six rabbits. All rabbits of this group had erythema and edema scores of 4 (severe) for both intact and abraded skin sites at 24 and 72 hours.

Information poorly documented, insuficient for classification.

Reference 2

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

A scientific review, data insufficient for assesment.

Principles of method if other than guideline:

Standard Draize dermal irritation assay.

GLP compliance:

not specified

Species:

rabbit

Strain:

not specified

Amount / concentration applied:

0.5g dossolved in appropiate solvent (concentration not speciffied)

Duration of treatment / exposure:

Patches were applied under 1 x1-inch gauze pads to the intact and abraded skin of six albino rabbits. The patches were attached to the skin with adhesive tape and the trunk of each rabbit was wrapped in a rubberized cloth sheath for 24 hours.

Number of animals:

6

Remarks on result:

other: Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant).

Irritant / corrosive response data:

Sodium Hexametaphosphate had a PII of 1.62 (mild irritant).

Interpretation of results:

study cannot be used for classification

Conclusions:

Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant).

Executive summary:

Powdered Sodium Hexametaphosphate had a PII of 1.62 (mild irritant) in the standard Draize dermal irritation assay using six rabbits.

Information poorly documented, insuficient for classification.

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

A scientific review.

Principles of method if other than guideline:

Evaluated using the Illustrated Guide for Grading Eye Irritation Caused by Hazardous Substances.

GLP compliance:

not specified

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

Animals weights from 1.6 to 2.1 kg

Vehicle:

water

Amount / concentration applied:

Ten milligrams of concentrated Sodium Hexametaphosphate or 0.1 ml of a 0.2% solution in water was instilled into the conjunctival sac of the eye.

Remarks on result:

other: Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.

Interpretation of results:

study cannot be used for classification

Conclusions:

Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and nonremissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.

Executive summary:

The test was performed with 6 New Zealand White rabbits. Ten milligram of concentrated Sodium Hexametaphosphate or 0.1 ml of a 0.2% solution in water was instilled into the conjunctival sac of the eye.

The untreated eye of each rabbit served as its control. The eyes were then observed at 24, 48, and 72 hours.

Under the conditions of this study, concentrated Sodium Hexametaphosphatewas corrosive and non remissible. The 0.2% solution of Sodium Hexametaphosphate was non irritating to the eyes of rabbits.