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EC number: 233-343-1 | CAS number: 10124-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Water solutions of different sodium meta- and polyphosphates were incubated in isolated small intestine obtained from rat or pig. The resulting phosphate species were analyzed by the paper chromatography method according to Karl-Krupa (Anal. Chem. 1956, 28: 1091) with small modifications. Two-dimensional development was used to analyse of the samples.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- Wistar
- Details on species / strain selection:
- Wistar male rats and pigs (sex not specified) were used.
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Adult male Wistar derived rats of about 250 g were fasted for 2 days to clear the intestine and then sacrificed with CO2. The small intestine was immediately excised and was flushed with 20 ml of warm saline and tied off into thee sections.Porcine small intestines were excised from hogs during slaughter at a local slaughter house and were taken to the laboratory. The first 2 m of each small intestine was used. These were flushed with 200 ml of warm saline and cut into 50 cm sections.
- Route of administration:
- infusion
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- 24h
- No. of animals per sex per dose / concentration:
- not applicable
- Control animals:
- no
- Preliminary studies:
- not performed
- Details on absorption:
- not examined
- Details on distribution in tissues:
- not examined
- Details on excretion:
- not examined
- Metabolites identified:
- yes
- Details on metabolites:
- Hydrolysis of polyphosphates owas fast in in vitro rat intestine. In 60 minutes, metaphosphates with n>4 are substantially hydrolyzed. This rate suggests that enzymatic hydrolysis is likely to be involved, since for polyphosphates with n>4 at best marginal hydrolysis in water is reported at this pH.Porcine intestine also gave significant hydrolysis of both ring and chain phosphates. Summarizing, the rate of hydrolysis for each compound was similar to that in rat intestine. Identified metabolites comprised ortho-, pyro-, trimeta-, tripoly-, and tetrapolyphosphates.
- Conclusions:
- Linear as well as circular polyphosphates are hydrolysed in both rat and porcine small intestine. This reaction is mediated by enzymes of the brush border membrane. The resulting metabolite is mainly orthophosphate.
- Executive summary:
Cyclic ring as well as linear polyphosphates including sodium trimeta-, tetrameta-, tripoly-, and hexametaphosphate were found to be enzymatically hydrolyzed in in vitro rat and porcine small intestine.
Sodium trimetaphosphate was reduced by 27.5% and 13.2% in rat and porcine small intestine after 1h, respectively. Sodium hexametaphosphate was reduced by 21.1% and 24.1% in rat and porcine small intestine after 1h, respectively. Sodium tripolyphosphate was reduced by 82.3% and 35% in rat and porcine small intestine after 1h, respectively.
The rate of hydrolysis in the in vitro intestine indicated an enzymic mechanism.
Reference
Description of key information
Supporting stud: The result of the study showede that linear as well as circular polyphosphates are hydrolysed in both rat and porcine small intestine. This reaction is mediated by enzymes of the brush border membrane. The resulting metabolite is mainly orthophosphate.
Key value for chemical safety assessment
Additional information
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