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Diss Factsheets
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EC number: 946-342-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2022-06-16 to 2022-11-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Inoculum of the aqueous phase of non-adapted activated sludge
- Source: Municipal sewage treatment plant, Hildesheim, Germany
- After the second washing the settled sludge was resuspended in mineral salts medium and was maintained in an aerobic conditions by aeration with CO2 free air until test start (3 days) at test temperature.
- The amount of inoculum used to initiate inoculation was 5.22 ml/L (25.0 mg/L dw) - Duration of test (contact time):
- 60 d
- Initial conc.:
- 22 mg/L
- Based on:
- test mat.
- Initial conc.:
- 52.6 mg/L
- Based on:
- ThOD
- Initial conc.:
- 57.6 mg/L
- Based on:
- ThOD
- Remarks:
- with nitrification
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- PRE-TREATMENT
- The test item was applied via a stock solution in silicone oil.
- The stock solution was prepared by weighing out of 11.1 g/L test item in a measuring flask and adding approx. 10 mL of silicone oil.
- The stock solution was shaken until the test item was fully dissolved.
- Upon visual checking, the final test solution was clear. 496.5 µL was pipetted into the brown glass bottles.
TEST CONDITIONS
- Composition of medium: Mineral salts medium according to OECD 301 F
- Test temperature: Nominal: 20 - 24 ± 1 °C; Actual: 21.8 – 22.5 °C
- Photoperiod: Dark
TEST SYSTEM
- Culturing apparatus: Closed bottles
- Number of culture flasks/concentration: 2 for the inoculum control, 2 for the inoculum control with silicone oil, 1 for the functional control, 1 for the functional control with silicone oil, 3 for the test item replicates, 3 for the test item replicates with silicone oil, 1 for the toxicity control, 1 for the toxicity control with silicone oil.
- Method used to create aerobic conditions: Headspace of air
- Measuring equipment: OxiTop OC110 controller with software Achat OC, WTW OxiTop measuring heads, WTW
SAMPLING
- Sampling frequency: daily
- Sampling method: The oxygen consumption was determined in the incubation vessels by the OxiTop measuring system
- Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 43.66
- Sampling time:
- 28 d
- Remarks on result:
- other: Test item solved in silicone oil for application due to low solubility in water
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 55
- Sampling time:
- 60 d
- Remarks on result:
- other: Test item solved in silicone oil for application due to low solubility in water
- Details on results:
- Degradation kinetics (%) of the test item with silicone oil:
-Day 9: Rep1 9%, Rep2 13%, Rep3 12%
-Day 19: Rep1 16%, Rep2 27%, Rep3 32%
-Day 28: Rep1 26%, Rep2 41%, Rep3 38%
-Day 42: Rep1 38%, Rep2 54%, Rep3 47%
-Day 52: Rep1 42%, Rep2 62%, Rep3 51%
-Day 60: Rep1 44%, Rep2 67%, Rep3 55%
Toxicity control with silicone oil:
- Day 2: 24%
- Day 14: 45%
- Day 28: 49%
- Day 60: 55%
In all test item replicates a formation of oxidized nitrogen lower the inoculum control level was observed. Based on these results the ThOD was used for evaluation. - Results with reference substance:
- Biodegradation of the functional control with silicone oil:
- Day 2: 50%
- Day 12: 76%
- Day 28: 78%
- Day 60: 80% - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The study showed that the test item is not readily biodegradable. The test item did not reach its pass level of biodegradation (60%) during the 60-d period.
- Executive summary:
The present study was conducted in order to evaluate the biodegradability of the test item by measuring its percentage of biodegradation with inoculum in a period of 60 days. The test method was performed following the OECD Test Guideline 301F and GLP.
The test item concentration was 22 mg/L. It was solved in silicone oil for its application due to its low water solubility. Benzoic acid was used as reference substance in the functional control as well as in the toxicity control. After the 60-d period the biodegradation of the test item was calculated to be 55% and it did not reach a plateau. Therefore, the test item is regarded as not readily biodegradable.
Reference
Description of key information
Not readily biodegradable: 55% after 60 days (OECD 301F)
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
The present study was conducted in order to evaluate the biodegradability of the test item by measuring its percentage of biodegradation with inoculum in a period of 60 days. The test method was performed following the OECD Test Guideline 301F and GLP.
The test item concentration was 22 mg/L. It was solved in silicone oil for its application due to its low water solubility. Benzoic acid was used as reference substance in the functional control as well as in the toxicity control. After the 60-d period the biodegradation of the test item was calculated to be 55% and it did not reach a plateau. Therefore, the tes item is regarded as not readily biodegradable.
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