Registration Dossier
Registration Dossier
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EC number: 203-870-1 | CAS number: 111-44-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- It is not clear if the administered dose refers to the 10 % solution prepared or to BCEE. This causes uncertainty in the interpretation of the results
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- No information provided
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-chloroethyl) ether
- EC Number:
- 203-870-1
- EC Name:
- Bis(2-chloroethyl) ether
- Cas Number:
- 111-44-4
- Molecular formula:
- C4H8Cl2O
- IUPAC Name:
- 1-chloro-2-(2-chloroethoxy)ethane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- propylene glycol
- Duration of exposure:
- 24 h
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 90 mg/kg bw
- 95% CL:
- >= 55 - <= 145
- Remarks on result:
- other: It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the BCEE content.
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 9 mg/kg bw
- 95% CL:
- >= 5.5 - <= 14.5
- Remarks on result:
- other: It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the ai content. As worst case scenario, it is assumed that the LD50 is based on the total applied material. Hence, the LD50 based on ai is 10% of the applied amount
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- Following exposure by skin contact to a 10 % Bis(2-chloroethyl) ether solution in propylene glycol for 24 hours, the rabbit LD50 was found to be 90 mg/kg bw. Assuming that the LD50 is based on the total applied material, the LD50 based on Bis(2-chloroethyl) ether is 10% of the applied amount, i.e., 9 mg/kg bw. This data classifies the substance in the Acute Catgeory I according to GHS criteria.
- Executive summary:
This handbook reports the results of an internal toxicity test from Dow Chemical Co. Following exposure by skin contact to a 10 % Bis(2-chloroethyl) ether solution in propylene glycol for 24 hours, the rabbit LD50 was found to be 90 mg/kg bw. It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the Bis(2-chloroethyl) ether content. As worst case scenario, it is assumed that the LD50 is based on the total applied material. Hence, the LD50 based on Bis(2-chloroethyl) ether is 10% of the applied amount, i.e., 9 mg/kg bw. This data classifies the substance in the Acute Category I according to GHS criteria.
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