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EC number: 911-296-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No irritation study is available on the registered substance (reaction mass of C12 -C13 acrylate). However the data are available on an analogue substance (reaction mass of C12 -C14 acrylate).
Indeed, Laurylacrylate (C12 -C14 acrylate) is slightly irritating to the skin or but not irritating to the eyes in rabbit's studies.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL of the undiluted test material
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- Readings were performed after 24 and 72 hours. If, at the second reading, distinct irritation was observed a third reading was performed after seven days. After the final reading all rabbits were killed and, in the case of eschar formation, the scab was removed to examine the nature of the underlying tissue damage.
- Number of animals:
- 12 (6 animals were treated on intact skin)
- Details on study design:
- TEST PROCEDURE Primary irritation to the skin was measured by a patch-test technique on the abraded and intact skin of albino rabbits. Twelve healthy adult New Zealand White albino rabbits were used for the test substance. Pretreatment: 24 hours prior to applying the material, the hair was removed from the backs of the animals with an electric clipper in such a way as to avoid abrasions.
Application procedure: The test substance was brought on the intact or abraded skin under a surgical patch measuring 1 inch x 1 inch. The patches were fixed to the application site by means of adhesive tape and the entire trunk of the rabbits was wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances. Abrasions: The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding. Evaluation of skin reactions: Skin reactions were evaluated by the method of Draize (1944).Draize (1944). J. Pharmacol. 82: 377-390 Calculation of Primary Irritation Index: A Primary Irritation Index was calculated as follows: all erythema and edema scores obtained after 24 and 72 hours (48 scores) are added together and divided by 24. The Primary Irritation Index was descriptively expressed according to the following classification: 0.0 - 0.5 non-irritant 0.6 - 3.0 slight irritant 3.1 - 5.0 moderate irritant 5.1 - 8.0 severe irritant - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 2.4
- Max. score:
- 8
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 27 h
- Score:
- 1.42
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 1.59
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 1.07
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: abraded skin
- Irritant / corrosive response data:
- After 24 hours, intact skin : very slight or well-defined thema and very slight edema .
After 24 hours, abraded skin: very slight or well-defined erythema, slight ischemia and slight edema.
After 72 hours, intact skin: very slight or well-defined erythema, slight scaliness and very slight edema.
After 72 hours, abraded skin: very slight erythema, slight scaliness and very slight edema.
On the abraded skin the test compound caused edema to a slightly higher degree than on the intact skin .
As to the other dermal effects observed there were no differences between reactions of the intact skin and those of the abraded skin . - Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- Based on the available data, the test item is considered to be slightly irritating in rabbit after 4 hours of exposure (on intact skin).
- Executive summary:
Primary irritation to the skin was measured by a patch-test technique on the abraded and intact skin of albino rabbits. Twelve healthy adult New Zealand White albino rabbits were used for the test substance. 24 hours prior to applying the material, the hair was removed from the backs of the animals with an electric clipper in such a way as to avoid abrasions. The test substance was brought on the intact or abraded skin under a surgical patch measuring 1 inch x 1 inch. The patches were fixed to the application site by means of adhesive tape and the entire trunk of the rabbits was wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances. Skin reactions were evaluated by the method of Draize (1944). All erythema and edema scores obtained after 24 and 72 hours (48 scores) were determined.
Mean values over 24 and 72 hours (intact skin) were 1.5 -1.5 -1.0 -1.0 -2.0 -1.5 for erythema score, and 0.5 -0.5 -0.0 -0.5 -1.0 -1.0 for oedema score. Based on the available data, the test item is considered to be slightly irritating in rabbit after 4 hours of exposure (on intact skin).
Reference
Generally, the following dermal effects were observed:
After 24 hours, intact skin: very slight or well-defined erythema and very slight edema.
After 72 hours, intact skin: very slight or well-defined erythema, slight scaliness and very slight edema.
On the abraded skin the test compound caused edema to a slightly higher degree than on the intact skin.
As to the other dermal effects observed, there were no differences between reactions of the intact skin and those of the abraded skin.
Individual
and average skin irritation scores:
|
Intact skin |
|
Abraded skin |
||||||
No. Animal |
24 h |
72 h |
No. animal |
24 h |
72 h |
||||
|
A |
B |
A |
B |
|
A |
B |
A |
B |
1 |
2 |
1 |
1 |
0 |
|
2 |
2 |
1 |
1 |
2 |
2 |
1 |
1 |
0 |
|
4 |
2 |
1 |
0 |
3 |
1 |
0 |
1 |
0 |
|
2 |
2 |
1 |
0 |
4 |
1 |
1 |
1 |
0 |
|
2 |
2 |
1 |
1 |
5 |
2 |
1 |
2 |
1 |
|
2 |
2 |
1 |
0 |
6 |
2 |
1 |
1 |
1 |
|
1 |
1 |
1 |
0 |
average |
1.7 |
0.8 |
1.2 |
0.3 |
|
2.1 |
1.8 |
1.0 |
0.3 |
Sum |
2.5 |
1.5 |
|
4.0 |
1.3 |
A: erythema
B: edema
Mean values over 24 and 72 hours (intact skin):
No. Rabbit |
Erythema |
Edema |
1 |
1.5 |
0.5 |
2 |
1.5 |
0.5 |
3 |
1.0 |
0.0 |
4 |
1.0 |
0.5 |
5 |
2.0 |
1.0 |
6 |
1.5 |
1.0 |
average | 1.42 | 0.6 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Method: Draize Test
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: 0.1 mL
- Duration of treatment / exposure:
- 168 hour(s)
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Comment: not rinsed
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 3
- Irritant / corrosive response data:
- No eye irritation was observed in this study 24 hours after exposure
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the available data, the test item is not considered to be eye irritating in rabbits.
- Executive summary:
In this in vivo eye irritation study, six healthy adult New Zealand White albino rabbits were used for the test substance. The eyes of the animals were examined before testing and only those animals without observable eye defects are used. 0.1 mL of the undiluted test substance was allowed to fall on the everted lower lid of one eye of each rabbit; the upper and lower eye lid were then carefully closed and subsequently held together for at least one second before releasing, to prevent loss of material.The other eye remaining untreated, served as a control. The eyes were not washed following instillation.The eyes were examined at one hour, 24, 48, 72 hours and 7 days after instillation of the test material. Eye reactions were evaluated by the method published by Draize and Kelley (1952). After 48, 72 hours and 7 days all scores were recorded as 0. No eye irritation was observed in the study.
Based on the results, the test substance is considered to be not irritating to the eyes.
Reference
The test compound caused slight lesions of the conjunctivae in all rabbits. After 24 hours these lesions had subsided completely.
Individual eye irritation scores:
---------------------------------
rabbit cornea iris conjunctivae Total score
opacity area redness chemosis discharge
-------------------------------------------------------------------------- -----------------
after 1 hour
1 0 0 0 1 0 0 2
2 0 0 0 1 1 0 4
3 0 0 0 1 0 0 2
4 0 0 0 1 0 0 2
5 0 0 0 1 0 0 2
6 0 0 0 1 0 0 2
after 24 hours
1 0 0 0 0 0 0 0
2 0 0 0 0 0 0 0
3 0 0 0 0 0 0 0
4 0 0 0 0 0 0 0
5 0 0 0 0 0 0 0
6 0 0 0 0 0 0 0
After 48, 72 hours and 7 days all scores were recorded as 0.
-------------------------------------------------------------------------- ------------------
Mean values over 24, 48, and 72 hours for the single animals for cornea, iris and conjunctivae were without exception zero. Thus, the eye irritation score was calculated to be zero.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
One in vivo study is available on the Laurylacrylate C12C14. The study was performed on rabbit and showed a mild and reversible skin irritation.
Primary irritation to the skin was measured by a patch-test technique on the abraded and intact skin of albino rabbits. Twelve healthy adult New Zealand White albino rabbits were used for the test substance. 24 hours prior to applying the material, the hair was removed from the backs of the animals with an electric clipper in such a way as to avoid abrasions. The test substance was brought on the intact or abraded skin under a surgical patch measuring 1 inch x 1 inch. The patches were fixed to the application site by means of adhesive tape and the entire trunk of the rabbits was wrapped with an impervious material to maintain the test patches in position and to retard evaporation of volatile substances. Skin reactions were evaluated by the method of Draize (1944). All erythema and edema scores obtained after 24 and 72 hours (48 scores) were determined.
Mean values over 24 and 72 hours (intact skin) were 1.5 -1.5 -1.0 -1.0 -2.0 -1.5 for erythema score, and 0.5 -0.5 -0.0 -0.5 -1.0 -1.0 for oedema score. Based on the available data, the test item is considered to be slightly irritating in rabbit after 4 hours of exposure (on intact skin).
Eye irritation
One in vivo study is available on the Laurylacrylate C12C14. In this in vivo eye irritation study, six healthy adult New Zealand White albino rabbits were used for the test substance. The eyes of the animals were examined before testing and only those animals without observable eye defects are used. 0.1 mL of the undiluted test substance was allowed to fall on the everted lower lid of one eye of each rabbit; the upper and lower eye lid were then carefully closed and subsequently held together for at least one second before releasing, to prevent loss of material.The other eye remaining untreated, served as a control. The eyes were not washed following instillation.The eyes were examined at one hour, 24, 48, 72 hours and 7 days after instillation of the test material. Eye reactions were evaluated by the method published by Draize and Kelley (1952). After 48, 72 hours and 7 days all scores were recorded as 0. No eye irritation was observed in the study.
Based on the results, the test substance is considered to be not irritating to the eyes.
Respiratory tract irritation
No specific study is available to evaluate the respiratory tract irritation.
However, an acute study by inhalation is available on laurylacrylate C12C14, and no irritation of the respiratory tract was observed after an exposure of 8hr at the saturated concentration (0.69 mg/l).
Justification for classification or non-classification
Based on the available data, no classification for irritation is required for the reaction mass of C12 -C13 acrylate according to the Regulation EC n°1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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