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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
STUDIES ON THE VALUE OF MERCUROCHROME AS A DISINFECTANT IN OPHTHALMIC WORK
Author:
FRANDSEN, H
Year:
1926
Bibliographic source:
Acta Ophthalmologica, 4: 48-52, 1926

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of the test chemical in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Merbromin
EC Number:
204-933-6
EC Name:
Merbromin
Cas Number:
129-16-8
Molecular formula:
C20H10Br2HgO6.2Na
IUPAC Name:
merbromin
Test material form:
solid: crystalline
Details on test material:
- Name of test material: disodium [2,7-dibromo-9-(2-carboxylatophenyl)-6-oxido-3-oxo-3H-xanthen-5-yl]mercurol
- Common name : Merbromin
- Molecular formula: C20H8Br2HgNa2O6
- Molecular weight: 750.6552 g/mol
- Smiles notation: c1ccc2c(c1)C(=O)OC23c4cc(c(cc4Oc5c3cc(c(c5[Hg]O)[O-])Br)[O-])Br.[Na+].[Na+]
- InChl: 1S/C20H9Br2O5.Hg.2Na.H2O/c21-13-5-11-17(7-15(13)23)26-18-8-16(24)14(22)6-12(18)20(11)10-4-2-1-3-9(10)19(25)27-20;;;;/h1-7,23-24H;;;;1H2/q;3*+1;/p-3
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
water
Controls:
not specified
Amount / concentration applied:
2% solution of the test chemical
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
1
Details on study design:
TEST SITE
- Area of exposure: conjunctivae

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Instillation of the 2% solution of the test chemical in the conjunctival sac of the animal did not cause any irritation to rabbit eyes.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Instillation of the 2% solution of the test chemical in the conjunctival sac of the animal did not cause any irritation to rabbit eyes. Hence, the test chemical can be considered to be not irritating to eyes.
Executive summary:

The ocular irritation potential of the test chemical was in rabbits. 2% solution of the test chemical was instilled into the eyes of 1 rabbit and observed for effects(duration of exposure, observation period not mentioned).

Instillation of the 2% solution of the test chemical in the conjunctival sac of the animal did not cause any irritation to rabbit eyes. Hence, the test chemical can be considered to be not irritating to eyes.