Registration Dossier
Registration Dossier
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EC number: 217-682-2 | CAS number: 1929-82-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed secondary source with dose decriptor provided only.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Test Item: A scientific advisory group review of the mode of action and carcinogenicity in B6C3F1 mice
- Author:
- B.L. Yano , J.F. Hardisty, J.C. Seely, B.E. Butterworth, E.E. McConnell, J.A. Swenberg, G.M. Williams, K.E. Stebbins, B.B. Golllapudi, D.L. Eisenbrandt
- Year:
- 2 008
- Bibliographic source:
- Regulatory Toxicology and Pharmacology 51 (2008) 53–65
- Reference Type:
- other: study report as cited in secondary source
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- Secondary literature source no data about the method was available.
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Nitrapyrin
- EC Number:
- 217-682-2
- EC Name:
- Nitrapyrin
- Cas Number:
- 1929-82-4
- Molecular formula:
- C6H3Cl4N
- IUPAC Name:
- 2-chloro-6-(trichloromethyl)pyridine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- no data available
- Details on exposure:
- no data available
- Duration of treatment / exposure:
- no data available
- Frequency of treatment:
- no data available
- Post exposure period:
- no data available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
800 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- no data available
- Positive control(s):
- no data available
Examinations
- Tissues and cell types examined:
- bone marrow
- Details of tissue and slide preparation:
- no data available
- Evaluation criteria:
- no data available
- Statistics:
- no data available
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- no data available
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
