Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 January - 8 February 1949
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted prior to GLP and Test guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949
Report date:
1949

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Groups of male rats were orally gavaged with test material and observed for two weeks.
GLP compliance:
no
Test type:
other: Range finding study

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6,8-trimethylnonan-4-ol
EC Number:
204-606-8
EC Name:
2,6,8-trimethylnonan-4-ol
Cas Number:
123-17-1
Molecular formula:
C12H26O
IUPAC Name:
2,6,8-trimethylnonan-4-ol
Details on test material:
- Name of test material (as cited in study report): 2,6,8-trimethyl nonanol

Test animals

Species:
rat
Strain:
Sherman
Sex:
male
Details on test animals or test system and environmental conditions:
No additional information available.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1% Tergitol 7 aqueous solution
Details on oral exposure:
Test material was a 20% dispersion in 1% Tergitol 7
Doses:
Rats were dosed with 7950, 15,800 and 31,600 mg/kg.
No. of animals per sex per dose:
5 males/dose level
Control animals:
no
Details on study design:
Rats were orally gavaged with a 20% solution in 1% Tergitol 7. Animals were observed for two weeks.

Rats weight ranged from 90 - 118 grams at time of dosing.
Statistics:
Method of Thompson used to calculate Range Finding LD50.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
13 700 mg/kg bw
Based on:
test mat.
95% CL:
11 200 - 16 700
Mortality:
31,600 mg/kg
Five of five rats died following dosing. Two rats died one day after dosing while three died two days after dosing.

15,800 mg/kg
Two of five rats died following dosing. One rat died one day and the other died two days after dosing.

7950 mg/kg
Zero of five rats died following dosing.
Clinical signs:
other: There were no remarkable symptoms evident after dosing.
Gross pathology:
Congestion of the visceral organs was observed.
Other findings:
No additional information available.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the study results, Trimethyl nonanol is a compound of low acute oral toxicity for rats with a range finding LD50 of 17,000 (12,200 to 23,800) mg/kg. It is a member of the same oral toxicity grade as ethanol.
Executive summary:

The acute oral toxicity of trimethyl nonanol was examined. The oral LD50 in male rats was 17,000 (12,200 - 23,800) mg/kg.