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Diss Factsheets
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EC number: 402-030-3 | CAS number: 624-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
In a dermal sensitization study with an aqueous solution containing 50 % (w/v) Substance H109360 (45% O-ethylhydroxylamine and approximately 5% ethanol), Dunkin-Hartley guinea pigs weighing 317-375 g were tested according to a method equivalent and similar to that described in OECD TG 406 (Skin Sensitisation). The control group contained 10 animals. 20 guinea pigs were used in the test group. Intradermal injections (0.05-0.1 ml) were performed with 3% of the test substance in water while topical inductions (0.2-3.0 ml) were carried out under occlusive conditions, 1 week after intradermal injections with 10% of the Substance H109360 in water. 2 weeks after topical induction exposure, challenge was performed epicutaneously (occlusive; 0.5 ml/animal) with 50% and 30% of Substance H109360 in water for a duration of 24 hours. Evaluation for sentisation was performed 24 and 48 hours post termination of exposure. No data on historical or positive control was given. Only 19 animals were evaluated since one animal lost treatment dressing (bandage) before end of the exposure period. This animal gave a negative result. No skin irritations were noticed in all animals of the control and animals challenged with 30% of the test substance. 3/19 (16%) animals treated with 50% of Substance H109360 gave positive results for skin sensitization (Central Toxicology Laboratories, 1987).
Migrated from Short description of key information:
Skin sensitization: The test substance does not cause contact skin sensitisation in the guinea pig maximization test.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
3/19 (16%) animals treated with 50% of Substance H109360 gave positive results for skin sensitization. This percentage is however lower than the threshold of 30% required for classification according to the 67/548/EEC Annex VI.
Justification for classification or non-classification
Skin sensitization
Ethoxyamine is listed in Annex I of EU Directive No. 67/548/EEC with the classification "may cause sensitisation by skin contact" (R43) and in Annex VI of EU Directive No. 1272/2008 with the classification "may cause allergic skin reaction" (Cat 1). These classifications will be maintained.
Respiratory Sensitization
No classifcation possible due to lack of data
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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