Registration Dossier
Registration Dossier
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EC number: 205-811-5 | CAS number: 152-97-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 Nov 1988 - 24 Apr 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- not specified
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.3
- Temp.:
- 25 °C
- pH:
- 7
- Conclusions:
- The n-octanol/water partition coefficient (logPow) is 2.3 (95 % confidence limits 2.0-2.5) measured at 25 °C and pH 7.
- Executive summary:
The n-octanol/water partition coefficient (logPow) was determined with the HPLC-method according to OECD guideline 117 to be 2.3 (95 % confidence limits 2.0-2.5) measured at 25 °C and pH 7. This method is based on the correlation of the reversed phase retention data of the test compound with those of the reference compounds with known log Pow values. The substance can be considered as a neutral molecule in the pH range of physiological interest. Therefore, no pH dependence of log Pow has to be taken into account.
Reference
Validity criteria for the measurement of the particion coefficient:
| Target condition according to guideline A.8: | Actual condition according to the study: | Validity criteria met: |
| For the measurement, substance-specific methods are preferred. Analytical methods which may be appropriate are: photometry, gas chromatography and high performance liquid chromatography. | HPLC was used as analytical method. | Yes |
| The temperature, the amount of test substance introduced in the test vessels, the volume of each phase in each vessel and the calculated total amount of test substance based on the analytical data shall be stated. | Not all data given in report. | Yes, with restrictions |
| The pH of the water used and of the aqueous phase during the experiment shall be stated. | Bidistilled water is used, so a pH of 7 is assumed. | Yes |
Description of key information
The n-octanol/water partition coefficient (logPow) is 2.3 (95 % confidence limits 2.0-2.5) measured at 25 °C and pH 7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.3
- at the temperature of:
- 25 °C
Additional information
The substance can be considered as a neutral molecule in the pH range of physiological interest.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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