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Diss Factsheets
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EC number: 943-368-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February to March 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Chemical analysis was performed in a non-GLP laboratory
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Chemical analysis was performed in a non-GLP laboratory
- Specific details on test material used for the study:
- - Source and lot/batch No. of test material: Rivertop Renewables, lot number BL04R1D1EA
- Expiration date of the lot/batch: February 1, 2018
- Purity test date: Purity - 52.9%
- Water solubility: Soluble in water
- Physical state - Brown liquid - Analytical monitoring:
- yes
- Remarks:
- Chemical analysis was performed at a non-GLP facility.
- Details on sampling:
- Duplicate samples, approximately 10 to 15 mL from each replicate test or control vessel, were taken for analysis at the start (0 hours) and end (48 hours) of the exposure period. Samples were kept cool after sampling and were transferred to the analytical laboratory within 24 hours of sampling.
- Vehicle:
- no
- Details on test solutions:
- All solutions of the test item were corrected for % solids (ie 52.9% by weight in water). 1.8904 g of test material was weighed into a 500 mL volumetric flask and made up to volume with laboratory dilution water.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Strain/clone: Not stated
- Source: Ministry of the Environment and Climate Change (Toronto, Ontario, Canada), continuous culture since 1988
- Age of parental stock (mean and range, SD):
- Feeding during test: not applicable
- Age at testing: <24 hour old neonates
ACCLIMATION
- Acclimation period:not applicable
- Acclimation conditions (same as test or not):
- Type and amount of food:
- Feeding frequency: daily with algae and proprietary Trout Chow.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
- Hardness:
- 200 mg/L as CaCO3
- Test temperature:
- 21.0 degrees centrigrade
- pH:
- Ranged between 8.3 and 8.5
- Dissolved oxygen:
- Ranged between 7.3 and 8.8 mg/L
- Salinity:
- Not applicable
- Conductivity:
- Ranged between 499 and 1743 umhos/cm
- Nominal and measured concentrations:
- Nominal exposure concentrations, 0 (control) and 2000 mg/L.
Measured concentration expressed as mean measured concentration, 0 (control) and 1480 mg/L. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL glass beakers
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 75 mL of test solution per vessel
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 15 mL per organism
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Laboratory well water
- Culture medium different from test medium: no
- Intervals of water quality measurement: 0 and 48 hours
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 400 to 800 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobility, 24 and 48 hours
- Reference substance (positive control):
- yes
- Remarks:
- Sodium chloride - 20 historical values presented
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 480 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Immobility after 48 hours was 5% in the 1480 mg/L treatment. The 48 hour EC50 of D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts to Daphnia magna was observed to be >1480 mg/L.
- Results with reference substance (positive control):
- Results are presented for sodium chloride and include 20 historical values.
- Reported statistics and error estimates:
- 48 hour EC50 was determined based on observation of the data.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the reported information an acceptable assessment of acute toxicity to Daphnia magna was achieved. Immobility after 48 hours was 5% in the 1480 mg/L treatment. The 48 hour EC50 of D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts to Daphnia magna was observed to be >1480 mg/L.
- Executive summary:
The effects of D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts to Daphnia magna were determined in a 48 hour static study. The study was carried out according to OECD guideline 202. In this study Daphnia magna were exposed to D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts over a test period of 48 hours in a limit study. Nominal concentrations were 0 (control) and 2000 mg/L, corresponding arithmetic mean measured concentrations were 0 and 1480 mg/L. After 48 hours there was 5% immobility in the 1480 mg/L treatment, the 48 hour EC50 was therefore observed to be >1480 mg/L based on the mean measured concentration.
Reference
Analytical results
Nominal concentration (mg/L) |
Measured concentration (mg/L) |
Average time weighted mean measured concentration (mg/L) |
|
0 hours (new) |
48 hours (old) |
||
Control |
<MDL |
<MDL |
0 |
Control |
<MDL |
<MDL |
|
2000 |
1439.81 |
1536.01 |
1480 |
2000 |
1442.0 |
1502.4 |
MDL =
Method detection limit = 8 mg/L
1= average of duplicate analysis, relative percent difference
<0.2%
Immobility results
Mean measured conc. (mg ai/L) |
Cumulative % immobility |
||
0 hours |
24 hours |
48 hours |
|
Control a |
0 |
0 |
0 |
Control b |
0 |
0 |
0 |
Control c |
0 |
0 |
0 |
Control d |
0 |
0 |
0 |
1480 a |
0 |
0 |
0 |
1480 b |
0 |
0 |
0 |
1480 c |
0 |
0 |
0 |
1480 d |
0 |
0 |
5 |
Description of key information
The effects of D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts to Daphnia magna were determined in a 48 hour static study. The study was carried out according to OECD guideline 202. In this study Daphnia magna were exposed to D-Glucose, reaction products with nitric acid and sodium nitrite (1:1), sodium salts over a test period of 48 hours in a limit study. Nominal concentrations were 0 (control) and 2000 mg/L, corresponding arithmetic mean measured concentrations were 0 and 1480 mg/L. After 48 hours there was 5% immobility in the 1480 mg/L treatment, the 48 hour EC50 was therefore observed to be >1480 mg/L based on the mean measured concentration.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 480 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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