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Diss Factsheets
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EC number: 221-717-7 | CAS number: 3209-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- publication
- Title:
- The Metabolism of 2:3 -, 2:6 - and 3:5 -Dichloronitrobenzene and the Formation of a Mercapturic Acid from 2:3:4:5-Tetrachloronitrobenzene in the Rabbit
- Author:
- Bray, H.G. et al.
- Year:
- 1 957
- Bibliographic source:
- Biochem J. 67(4):607-16
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Determination of metabolites excreted in urine of rabbits after administration of the test material by stomach tube
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichloro-3-nitrobenzene
- EC Number:
- 221-717-7
- EC Name:
- 1,2-dichloro-3-nitrobenzene
- Cas Number:
- 3209-22-1
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,2-dichloro-3-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2,3- Dichloronitrobenzene
- Analytical purity: no data
- Source: Bayer Products Ltd.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2-3 kg
Administration / exposure
- Route of administration:
- other: stomach tube
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw
- No. of animals per sex per dose / concentration:
- 6
- Control animals:
- no
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The main products excreted in urine were phenols, conjugated with glucuronic and sulphuric acids, and dichloroanilines. The phenols detected were: 2-Amino-3,4-dichlorophenol, 3-Amino-4,5-dichlorophenol, 4-Amino-2:3-dichlorophenol and 4,5-Dichloro-3-nitrophenol. No mercapturic acids were detected in the urines.
Any other information on results incl. tables
About 5% of a dose of 2,3 -dichloronitrobenzene is unabsorbed, the greater part of the unabsorbed material being reduced to the aniline. The test substance was not found in urine in the form of mercapturic acid. A large proportion of the dose was excreted as glucosiduronic acid and ethereal sulphate, indicating hydroxylation of the test substance. The ethereal sulphate is presumably formed from amino or nitro-dichlorophenols. With 2,3 -dichloronitrobenzene considerable reduction occurred and most of the base was excreted as such. From 2:3 -Dichloronitrobenzene significant amounts of the aniline were excreted combined.
Hence, the main metabolic pathways of 2,3 -dinitrochloronitrobenzene are reduction and hydroxylation, leading to the formation of 2-Amino-3,4-dichlorophenol, 3-Amino-4,5-dichlorophenol, 4-Amino-2:3-dichlorophenol and 4,5-Dichloro-3-nitrophenol and subsequent glucoronidation and sulfatation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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