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Diss Factsheets
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EC number: 205-132-4 | CAS number: 134-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- To determine the rate of hydrolysis of test chemical.
- GLP compliance:
- no
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on sampling:
- -Test chemical was purchased from Fluka Chemical Company
Preparation:
-3 ml of test chemical was added to 300 ml of deionized water which had been sterilized via autoclave.
-The mixture was stirred for 12 h at 24°C.
-No. of aliquots: 3 (50ml of each) - Buffers:
- 0.2 M phosphate buffer media at pH 5, 7 and 9
- Details on test conditions:
- -Three aliquots were injected into three sterile solutions (50 ml of each) of 0.2 M phosphate buffer having pH 5.0, 7.0 and 9.0, respectively.
-Solutions were stored at 24.5°C in the dark.
-Samples of each solution were taken for HPLC analysis. - Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- % Recovery:
- > 96 - < 100
- pH:
- 5
- Temp.:
- 25 °C
- Duration:
- 38 d
- Remarks on result:
- other: other details not available
- % Recovery:
- > 93 - < 97
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 38 d
- Remarks on result:
- other: other details not available
- % Recovery:
- > 91 - < 97
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 38 d
- Remarks on result:
- other: other details not available
- Remarks on result:
- not measured/tested
- Details on results:
- Study was carried out to determine percent rate of hydrolysis of test chemical. The Percent recovery of test chemical after 38 days at pH 5, 7 and 9 was determined to be 100-96%, 97-93% and 97-91%, respectively.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Study was carried out to determine percent rate of hydrolysis of test chemical. The Percent recovery of test chemical after 38 days at pH 5, 7 and 9 was determined to be 100-96%, 97-93% and 97-91%, respectively.
- Executive summary:
A 38 days study was conducted to determine the rate of hydrolysis of test chemical at the temperature of 25°C. Test solution was prepared by adding 3ml of test chemical to 300ml of deionized water which was stirred for 12h. Phosphate buffer media was used at pH 5, 7 and 9. Hence, after 38 days the percent recovery of test chemical at pH 5, 7 and 9 was determined to be 100-96%, 97-93% and 97-91%, respectively. Therefore, from the above value, it can be said that the test chemical was non-hydrolysable.
Reference
Test chemical was not subject to hydrolysis at 25°C.
Description of key information
A 38 days study was conducted to determine the rate of hydrolysis of test chemical at the temperature of 25°C. Test solution was prepared by adding 3ml of test chemical to 300ml of deionized water which was stirred for 12h. Phosphate buffer media was used at pH 5, 7 and 9. Hence, after 38 days the percent recovery of test chemical at pH 5, 7 and 9 was determined to be 100-96%, 97-93% and 97-91%, respectively. Therefore, from the above value, it can be said that the test chemical was non-hydrolysable.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 5.5 yr
Additional information
Following different studies includes experimental and estimated studies for the test chemical to observe the hydrolysis of test chemical in water.
A 38 days study was conducted to determine the rate of hydrolysis of test chemical at the temperature of 25°C. Test solution was prepared by adding 3ml of test chemical to 300ml of deionized water which was stirred for 12h. Phosphate buffer media was used at pH 5, 7 and 9. Hence, after 38 days the percent recovery of test chemical at pH 5, 7 and 9 was determined to be 100-96%, 97-93% and 97-91%, respectively. Therefore, from the above value, it can be said that the test chemical was non-hydrolysable.
In next study, the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant of test chemical was determined to be 0.042 L/mol-sec with a half-life value of 5.5 yrs and 200 days at pH 7.0 and 8.0, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
Based on the above value, the test chemical determined to be non-hydrolysable.
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