Registration Dossier
Registration Dossier
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EC number: 813-266-5 | CAS number: 45101-66-4
Endpoint summary
Administrative data
Description of key information
Additional information
No experimental data for 6-chlorohexyl methacrylate is available to assess the biodegradation in water of this substance. The substance is predicted no ready biodegradable by BIOWIN 4.10 using the smile notation ClCCCCCCOC(=O)C(=C)C. A different values regarding the biodegradability was indicated for the group of similar substance short chain alkyl methacrylates and in particular for the most similar substance 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier). In fact, in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) the esters of the category are rapidly biodegraded and completely mineralized. In particular, experimental data are available for the most similar short chain alkyl methacrylates 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6. In SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2 -EHMA a study conducted in 1998 according to OECD 301C is reported: 2-EHMA is ready-biodegradable based on 88% of biodegradation in water registered after 28 days (Ref. CERI, 1998, Report No. 20670D, CERI, Chemicals Evaluation and Research Institute, Japan, unpublished data on 2-EHMA).
Based on the similar physical-chemicals properties of 6-chlorohexyl methacrylate and 2-ethylhexyl methacrylate and based on experimental data reported for all short chain alkyl methacrylates in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004), 6-chlorohexyl methacrylate is reasonably ready-biodegradable as all the other methacrylates. The prediction of BIOWIN 4.10 for 6-chlorohexyl methacrylate is very precautionary and it is not supported by experimental data for similar substances. As conclusion 6-chlorohexyl methacrylate is considered ready-biodegradable.
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