Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when 3,4 -dimethoxyphenethylamine (CAS 120-20-7) introduced in appropriate low concentrations
Key value for chemical safety assessment
Additional information
The inhibitory effect of 3,4-dimethoxyphenethylamine (CAS 120 -20 -7) has been investigtaed in three studies. The effect on the respiration activity of activated sludge from a municipal sewage treatment plant was investigated following ISO 8192 (draft). As this study is similar to OECD 209, it was selected as key study. The respiration inhibition was not affected in a limit test with 1000 mg/L. The 30 -min EC20 and EC50 were determined to be greater than 1000 mg/L (BASF AG, 1988, report no. 01.0401/88).
Two additional studies were performed according to the German Industrial Standard DIN 38412, part 8, investigating the growth inhibition of Pseudomonas putida by the substance. In one test, the17 -h EC10 was determined to be 141 mg/L without pH-adjustment (17 -h EC50 = 200 mg/L; BASF AG, 1988, report no. 9/0844/88). In a second test with similar conditions, the effect values were almost identical (17 -h EC10 = 141 mg/L; 17 -h EC50 = 208 mg/L). In addition to the test solutions without pH-adjustment, the highest test concentration was also tested in parallel after pH-adjustment (initial pH = 7.1). No significant effect on the growth was observed (7% reduction). In test solutions up to 62.5 mg/L the initial pH was up to 7.7. In higher test concentrations (125 - 1000 mg/L), the pH was in a range beteen 9.1 and 10.3. Therefore, it can be concluded that the pH shift induced by high test item concentrations is responsible for the growth inhibition on P. putida.
The results are supported by a study with the structurally similar substance 3,4-Dimethoxyphenylacetonitrile (CAS 93-17-4). The effect of the substance on the respiration activity of municpal activated sludge was investigated according to OECD 209 under GLP. The 30 -min EC20 was determined to be ca. 230 mg/L, the EC50 was ca. 800 mg/L (BASF AG, 2003; report no. 02/0651/08/1)
Based on available data, it can be concluded that the inhibition of the degradation activity of activated sludge is not anticipated when the substance is introduced in appropriately low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.