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EC number: 223-358-1 | CAS number: 3852-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Methyl 3-methoxypropionate
- EC Number:
- 223-358-1
- EC Name:
- Methyl 3-methoxypropionate
- Cas Number:
- 3852-09-3
- Molecular formula:
- C5H10O3
- IUPAC Name:
- methyl 3-methoxypropanoate
- Details on test material:
- - clear colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Limited, Margate, Kent, England
- Age at study initiation: 4-6 weeks
- Weight at study initiation: 101-150g (prior to dosing (day 1))
- Fasting period before study: access to food only was prevented overnight prior to and approximately 4 hrs after dosing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23 (mean daily minimum-maximum)
- Humidity (%): 57 (mean daily)
- Air changes (per hr): approximately 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2.0, 3.2, 5.0 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed soon after dosing and at frequent intervals for the remainder of day 1, on subsuquent days the animals were observed once in the morning and again at the end of the experimental day; individual bodyweights on days 1 (day of dosing), 8, 15 and death
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 600 - 5 000
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 900 - 6 100
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 100 - 4 400
- Mortality:
- There were deaths among male and female rats following a single oral dose at 5.0 g/kg, and one female rat died at a dose of 3.2 g/kg. Deaths occurred within 1 h of dosing until day 2 in male and female rats.
- Clinical signs:
- other: Pilo-erection was observed in all rats within 5 min of dosing. This was accompanied by increased salivation in all rats dosed at 2.0 and 3.2 g/kg bw, and in a majority of rats dosed at 5.0 g/kg bw. Pilo-erection persisted throughout the remainder of day 1
- Gross pathology:
- Autopsy of the rats that died during the study revealed slightly congested lungs in one male and one female rat. No macroscopic abnormalities were seen in any of the other rats that died.
Terminal autopsy findings of surviving rats were normal.
Applicant's summary and conclusion
- Conclusions:
- The acute median lethal oral dose (LD50) and their 95% CL limits to female/male rats combined is: 4.2 (3.6-5.0) g/kg bodyweight.
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