Registration Dossier
Registration Dossier
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EC number: 202-885-0 | CAS number: 100-74-3
Endpoint summary
Administrative data
Description of key information
In a key skin sensitisation test following no specific guideline, but similar to OECD guideline 429, N-ethylmorpholine was found to be not sensitising (Holsapple MP, Wiescinsky CM, 1997).
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitisation potential of N-ethylmorpholine was investigated based on principles of the OECD guideline 429 (LLNA) approach with female Balb/c mice. Five animals were tested by dose group in four separate trials including 1 vehicle control group and 3 positive control groups. Solutions with 30% vol/vol test substance in acetone/olive oil (4:1) were applied to the ear once daily for three consecutive days. The test item elicited an SI value <3 and is considered to be not skin sensitising.
Short description of key information:
In a key skin sensitisation test following no specific guideline, but similar to OECD guideline 429, N-ethylmorpholine was found to be not sensitising (Holsapple MP, Wiescinsky CM, 1997).
Justification for selection of skin sensitisation endpoint:
Only one reliable study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data and according to the criteria of the CLP Regulation (EC) 1272/2008, NEM should not be classified for Skin Sensitisation.
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