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EC number: 700-208-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-11-10 - 2009-01-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The GLP study was conducted according to an internationally accepted guideline. All study parameters are based on the specific guideline.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- yes
- Remarks:
- The number of replicates of the treatment groups reference item and toxicity control were reduced from 2 to 1.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- yes
- Remarks:
- The storing of the samples at < -18 °C was prolonged from 14 to 28 days.
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- As microbial source (inoculum) for the test a fresh sample from the secondary effluent of a sewage treatment plant was used (sampling date: 13.11.2008). Before test start, the collected sample was decanted and filtered through a coarse filter paper.
About 1 hour after sampling at the sewage treatment plant, the inoculum was used in the test (< 0.5 mL/L mineral medium). - Duration of test (contact time):
- 28 d
- Initial conc.:
- 64 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- The test item dissolved in mineral medium was inoculated with micro-organisms (inoculum) from a mixed population and kept in conical glass flasks (1 L glass flask) at diffuse light and constant temperature.
Additionally a control group (mineral medium with inoculum), a reference item group (mineral medium with inoculum + reference item) and a toxicity control group (mineral medium with inoculum + test item + reference item) were run in parallel.
The degradation of the test item or reference item was followed by DOC analysis at frequent intervals over a 28-day period.
The degree of biodegradation was calculated by expressing the concentration of DOC removed as a percentage of the concentration initially presented. - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 4.9
- Sampling time:
- 5 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 30.5
- Sampling time:
- 11 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 30.5
- Sampling time:
- 20 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 32.5
- Sampling time:
- 25 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 32
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The biodegradation of N-[3(5)-Methyl-1H-pyrazol-1-yl-methyl]acetamide was determined according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). The biodegradation rate of the test item at a concentration of 64 mg/L mineral medium was calculated to be about 32 % after the 28-day test period. Since the degree of biodegradation of the test item did not reach 70 % (based on DOC) within a 10-day window (beginning at a degradation rate of 10 %), the test item cannot be classified as readily biodegradable. The biodegradation rate of the toxicity control was calculated to be about 64 % at the end of the test period (day 28). Therefore, the test item cannot be assumed to be inhibitory (required: 35 % biodegradation).
- Executive summary:
The biodegradation of N-[3(5)-Methyl-1H-pyrazol-1-yl-methyl]acetamide was determined according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). The biodegradation rate of the test item at a concentration of 64 mg/L mineral medium was calculated to be about 32 % after the 28-day test period. Since the degree of biodegradation of the test item did not reach 70 % (based on DOC) within a 10-day window (beginning at a degradation rate of 10 %), the test item cannot be classified as readily biodegradable. The biodegradation rate of the toxicity control was calculated to be about 64 % at the end of the test period (day 28). Therefore, the test item cannot be assumed to be inhibitory (required: 35 % biodegradation).
Reference
Results with test item:
Sampling day |
|
Measured Dissolved Organic Carbon (POC) [mg/L mineral medium] |
|
Biodegradationrate [%] |
|||
|
Control (blank) |
Test item(64mg/L) |
|
||||
|
Replicate |
|
Replicate |
|
|
||
|
I |
II |
mean |
I |
II |
mean |
|
0 |
1.701 |
2.297 |
1.999 |
35.36 |
37.18 |
36.27 |
0 |
4 |
0.807 |
1.648 |
1.2275 |
35.72 |
36.22 |
35.97 |
-1.38 |
5 |
1.049 |
1.014 |
1.0315 |
33.53 |
33.74 |
33.64 |
4.87 |
7 |
1.163 |
0.800 |
0.9815 |
26.95 |
26.07 |
26.51 |
25.51 |
8 |
1.210 |
1.374 |
1.292 |
26.34 |
25.57 |
25.96 |
28.04 |
11 |
1.105 |
1.141 |
1.123 |
24.97 |
24.93 |
24.95 |
30.47 |
13 |
0.803 |
1.238 |
1.0205 |
24.58 |
22.76 |
23.67 |
33.91 |
15 |
1.122 |
1.317 |
1.2195 |
25.24 |
23.91 |
24.58 |
31.85 |
18 |
0.934 |
0.957 |
0.9455 |
23.77 |
23.03 |
23.40 |
34.48 |
20 |
1.312 |
1.773 |
1.5425 |
26.12 |
24.61 |
25.365 |
30.49 |
22 |
2.069 |
1.866 |
1.9675 |
25.85 |
25.13 |
25.49 |
31.36 |
25 |
1.211 |
1.411 |
1.311 |
24.93 |
23.97 |
24.45 |
32.48 |
27 |
1.703 |
1.653 |
1.678 |
25.04 |
25.12 |
25.08 |
31.71 |
28 |
1.383 |
1.862 |
1.6225 |
24.88 |
24.96 |
24.92 |
32.02 |
Results with reference substance:
Sampling day |
|
Measured Dissolved Organic Carbon (DOC) [mg/L mineral medium] |
Biodegradationrate t%] |
||
|
|
Control (blank) |
|
Reference item |
|
|
Replicate |
|
(100mg/L) |
|
|
|
I |
II |
mean |
|
|
0 |
1.701 |
2.297 |
1.999 |
30.57 |
0 |
4 |
0.807 |
1.648 |
1.2275 |
20.94 |
31.50 |
5 |
1.049 |
1.014 |
1.0315 |
4.52 |
85.21 |
7 |
1.163 |
0.800 |
0.9815 |
3.52 |
88.49 |
8 |
1.210 |
1.374 |
1.292 |
3.38 |
88.94 |
11 |
1.105 |
1.141 |
1.123 |
1.96 |
93.59 |
13 |
0.803 |
1.238 |
1.0205 |
2.35 |
92.31 |
15 |
1.122 |
1.317 |
1.2195 |
2.45 |
91.99 |
18 |
0.934 |
0.957 |
0.9455 |
2.63 |
91.40 |
20 |
1.312 |
1.773 |
1.5425 |
5.08 |
83.38 |
22 |
2.069 |
1.866 |
1.9675 |
4.73 |
84.53 |
25 |
1.211 |
1.411 |
1.311 |
2.51 |
88.81 |
27 |
1.703 |
1.653 |
1.678 |
3.42 |
88.81 |
28 |
1.383 |
1.862 |
1.6225 |
2.88 |
90.58 |
Description of key information
The biodegradation of N-[3(5)-Methyl-1H-pyrazol-1-yl-methyl]acetamide was determined according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). The biodegradation rate of the test item at a concentration of 64 mg/L mineral medium was calculated to be about 32 % after the 28-day test period. Since the degree of biodegradation of the test item did not reach 70 % (based on DOC) within a 10-day window (beginning at a degradation rate of 10 %), the test item cannot be classified as readily biodegradable. The biodegradation rate of the toxicity control was calculated to be about 64 % at the end of the test period (day 28). Therefore, the test item cannot be assumed to be inhibitory (required: 35 % biodegradation).
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, not fulfilling specific criteria
Additional information
N-[3(5)-Methyl-1H-pyrazol-1-yl-methyl]acetamide is considered as not readily biodegradable.
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