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EC number: 261-521-9 | CAS number: 58958-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-07-29 until 2015-08-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with current guidelines and GLP compliance.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): sewage treatment plant
Ruhrverband Kläranlage, Sunthelle 6, 57392 Schmallenberg, Germany
- Date of sampling: 29th July 2015
- Storage conditions: No storage
- Preparation of inoculum for exposure: No washing, the concentration was adjusted to 3.0 g/L and verified by dry mass
measurement.
- Pretreatment: Kept aerobic until use
- Concentration of sludge in the test: 29.6 mg dry mass/litre - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- (20 mg test mat. = 60.5 mg ThOD ; 100 mg test mat. = 302.3 mg ThOD)
- Details on study design:
- - The concentration in the test assays were 20 mg per litre mineral test medium (5 mg/250 mL) and 100 mg per litre mineral test medium (25 mg/250 mL), respectively. 20 mg test item correspond to 60.5 mg ThOD. 100 mg test item correspond to 302.3 mg ThOD. The required amount of test item was added directly on a weight basis via Teflon discs. Subsequently, the required volume of aqueous reference stock solution and
mineral medium were added to the vessels.
- The concentration in the test vessels with reference item (procedural control, toxicity control) was 100 mg per litre mineral test medium (25 mg/250 mL).
- A further solution containing both test and reference item at the same concentrations as in the individual solutions (test item 100 mg/L, reference item 100 mg/L) was prepared to determine the possible toxicity of the test item against the inoculum.
- Further flasks with mineral medium only were prepared for inoculum controls.
- Abiotic controls were also prepared to measure any possible abiotic degradation; a solution of the test item at about 100 mg/L was sterilized by the addition of 1 mL/L HgCl2 (10 g/L).
- In all test assays except of the abiotic controls, 2.04 mL of the inoculum stock solution were transferred for inoculation (per 250 mL) resulting in a concentration of 29.6 mg dry mass/litre (7.41 mg dry mass/250 mL). - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 81
- St. dev.:
- 8.2
- Sampling time:
- 28 d
- Remarks on result:
- other: 20 mg/L test mat.
- Parameter:
- % degradation (O2 consumption)
- Value:
- 53.8
- St. dev.:
- 4.2
- Sampling time:
- 28 d
- Remarks on result:
- other: 100 mg/L test mat.
- Details on results:
- The test material was degraded by an average of 75 % within the 10-day-window in the 20 mg/L assay. Since 20 mg test material correspond with 60.5 mg ThOD ( therefore, meeting the required concentration of 50-100 mg ThOD/L), the result fulfills the requirements for ready biodegradability according to the OECD 301 guideline.
- Results with reference substance:
- The reference item was degraded by an average of 89 % by Exposure Day 14, thus confirming suitability of the activated sludge. At the end of the test (Day 28), the reference item was degraded by an average of 94 %.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- According to the guideline, Diisostearyl malate can be considered as being readily biodegradable.
- Executive summary:
At the Fraunhofer Institute for Molecular Biology and Applied Ecology the ready biodegradability of the test item was investigated according to the manometric respirometry test design and carried out according to the OECD guideline for Testing of Chemicals No. 301 F (1992) and the Council Regulation (EC) No 440/2008 of 30 May 2008.
The ready biodegradability of the test item was investigated at a concentration of 100 mg/L (ThOD = 302 mg/L) and 20 mg/L (ThOD = 61 mg/L), respectively, in a manometric respirometry test using domestic aerobic activated sewage sludge incubated at 22°C in the dark over 28 days under continuous stirring. The biochemical oxygen demand (BOD) was measured daily and the percentage degradation was calculated from the theoretical oxygen demand (ThOD) after correcting for the BOD of inoculum controls.
The biodegradation of Isooctadecyl pivalate in the static test was found to be at mean 54 % with a standard deviation of 4.2 % for a concentration of 100 mg test item per liter and at mean 81 % with a standard deviation of 8.2 % for a concentration of 20 mg test item per liter after 28 days. For a concentration of 100 mg test item per liter biodegradation within the 10-day-window was found to be 38 %. For a concentration of 20 mg test item per liter biodegradation within the 10-day-window was found to be 75 %. The test item had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration.
In the procedural controls, the reference substance sodium benzoate was degraded by an average of 89 % by exposure day 14, and reached an average biodegradation of 94 % by the end of the test (day 28), thus confirming suitability of the activated sludge.
Reference
Percent degradation. Degradation (%) after 14 days.
vessel |
Test suspension |
Test suspension |
Abiotic |
Procedural control |
Toxicity |
1 |
26.6 |
73.6 |
0.0 |
91.0 |
34.9 |
2 |
30.9 |
60.4 |
0.0 |
86.8 |
38.3 |
Mean |
28.8 |
67.0 |
0.0 |
88.9 |
36.6 |
SD |
3.0 |
9.4 |
0.0 |
3.0 |
2.4 |
Percent degradation. Degradation (%) after 28 days.
vessel |
Test suspension |
Test suspension |
Abiotic |
Procedural control |
Toxicity |
1 |
56.7 |
86.8 |
0.0 |
95.2 |
46.8 |
2 |
50.8 |
75.3 |
0.7 |
93.4 |
50.4 |
Mean |
53.8 |
81.0 |
0.3 |
94.3 |
48.6 |
SD |
4.2 |
8.2 |
0.5 |
1.3 |
2.6 |
Description of key information
Readily biodegradable: 81% after 28 d (O2 consumption, OECD 301F)
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The ready biodegradability of Isooctadecyl pivalate (CAS 58958-60-4) was investigated according to the manometric respirometry test design and carried out according to the OECD 301 F.
The ready biodegradability of the test item was investigated at a concentration of 100 mg/L (ThOD = 302 mg/L) and 20 mg/L (ThOD = 61 mg/L), respectively, in a manometric respirometry test using domestic aerobic activated sewage sludge incubated at 22°C in the dark over 28 days under continuous stirring. The biochemical oxygen demand (BOD) was measured daily and the percentage degradation was calculated from the theoretical oxygen demand (ThOD) after correcting for the BOD of inoculum controls.
The biodegradation of Isooctadecyl pivalate in the static test was found to be at mean 54 % with a standard deviation of 4.2 % for a concentration of 100 mg test item per liter and at mean 81 % with a standard deviation of 8.2 % for a concentration of 20 mg test item per liter after 28 days. For a concentration of 100 mg test item per liter biodegradation within the 10-day-window was found to be 38 %. For a concentration of 20 mg test item per liter biodegradation within the 10-day-window was found to be 75 %. The test item had no inhibitory effect on the activity of activated sludge microorganisms at the tested concentration.
In the procedural controls, the reference substance sodium benzoate was degraded by an average of 89 % by exposure day 14, and reached an average biodegradation of 94 % by the end of the test (day 28), thus confirming suitability of the activated sludge.
In conclusion, the test substance can be considered to be readily biodegradable according to the OECD criteria.
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