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EC number: 227-565-8 | CAS number: 5891-21-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Guideline study to GLP certification with no deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-chloropentan-2-one
- EC Number:
- 227-565-8
- EC Name:
- 5-chloropentan-2-one
- Cas Number:
- 5891-21-4
- Molecular formula:
- C5H9ClO
- IUPAC Name:
- 5-chloropentan-2-one
- Test material form:
- liquid
- Remarks:
- dark brown
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material:
5-Chloropentan-2-one (CAS-No.: 5891-21-4), Sanofi Chimie
- Purity: 95.9%
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
Nominal concentrations were 100, 45.5, 20.7, 9.4 and 4.3 mg/L
Geometric mean concentrations were 81.8, 39.8, 18.8, 8.43 and 3.06 mg/L
Samples collected from all test concentrations for analysis at 0, 24 and 48 hours.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The test media were prepared just before introduction of the daphnids (= start of the test) and test medium renewal on Day 1.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:
Water flea
- Strain/clone:
Daphnia magna (Straus), clone 5
- Age at study initiation (mean and range, SD):
From 3.5 to 21.0 hours old
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Remarks:
- Elendt M4 medium
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- None
Test conditions
- Hardness:
- No data (Elendt M4 medium)
- Test temperature:
- 19.1 to 20.1 °C across the test concentrations, replicates and test duration.
- pH:
- 7.5 to 8.1 across the test concentrations, replicates and test duration.
- Dissolved oxygen:
- 8.3 to 9.1 mg/L across the test concentrations, replicates and test duration.
- Salinity:
- Not applicable
- Conductivity:
- No data (Elendt M4 medium)
- Nominal and measured concentrations:
- Nominal concentrations were 100, 45.5, 20.7, 9.4 and 4.3 mg/L
Geometric mean concentrations were 81.8, 39.8, 18.8, 8.43 and 3.06 mg/L - Details on test conditions:
- TEST SYSTEM
- Renewal rate of test solution (frequency/flow rate):
Once at 24 hours
- No. of organisms per vessel:
5
- No. of vessels per concentration (replicates) 4:
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Photoperiod:
16 h light : 8 h dark - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 81.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 81.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 81.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 81.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- All reported results refer to geometric mean measured concentrations, since the test item concentrations were not within ± 20% of the nominal or measured initial concentrations during the test.
- Results with reference substance (positive control):
- EC50 after 24 hours was determined to be 1.48 mg test item/L, indicating that the sensitivity of the daphnids was consistent with the level proposed by the OECD 202 guideline (EC50-24 h between 0.6 and 2.1 mg potassium dichromate/L).
- Reported statistics and error estimates:
- The 24-hour and 48-hour EC50, EC20 and EC10 and the 95 % confidence limits were calculated by probit analysis. The NOEC and LOEC after 24 and 48 hours were determined directly from the raw data.
The software used to perform the statistical analysis was ToxRat Professional, Version 3.2.1, ToxRat Solutions GmbH.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The reliable (K1) OECD 202 Guideline study found that acute toxicity was observed in Daphnia magna resulting in a 48-hr EC50 of >81.8 mg/L. based on measured geometric mean.
- Executive summary:
The reliable (K1) OECD 202 Guideline study found that acute toxicity was observed in Daphnia magna resulting in a 48-hr EC50 of >81.8 mg/L. based on measured geometric mean. Other endpoint results are as follows:
48h-NOEC = 81.8 mg/L
48h-LOEC = >81.8 mg/L
48h-EC10= >81.8 mg/L
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