Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 930-964-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method was not according to any guideline. Monochloroacetic acid binding of in vitro sulfhydryl (SH) groups was examined as a possible mechanism of toxicity. No GLP.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Monochloroacetic acid binding of in vitro sulfhydryl (SH) groups was examined as a possible mechanism of toxicity. In vitro binding of monochloroacetic acid to cysteine sulfhydryl groups was determined by a colorimetric sulfhydryl analysis (Sedlak and Lindsay, 1968). Test substance (60 µM) was added to an aqueous solution of 60 µM cysteine-HCl.
- GLP compliance:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): monochloroacetic acid
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Rats were decapitated and their livers perfused via the central portal vein using 10 mL of 0.1 M Tris buffer (pH 7.4). Livers were excised, weighed and homogenized in 2 volumes 0.1 M Tris buffer (pH 7.4) using a motor-driven Potter-Elvehjem homogenizer.
Administration / exposure
- Route of administration:
- other: In vitro method
- Vehicle:
- water
- Details on exposure:
- Monochloroacetic acid was added to an aqueous solution of 60 µM cysteine-HCl.
- Duration and frequency of treatment / exposure:
- No data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
60 and 120 µM
- No. of animals per sex per dose / concentration:
- In vitro method.
- Control animals:
- yes
- Positive control reference chemical:
- No data.
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
Monochloroacetic acid did not reduce significantly alkylate sulfhydryl groups of cysteine in vitro.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: MCA did not reduce significantly alkylate sulfhydryl groups of cysteine in vitro.
Monochloroacetic acid did not reduce significantly alkylate sulfhydryl groups of cysteine in vitro. - Executive summary:
Monochloroacetic acid binding of in vitro sulfhydryl (SH) groups was examined as a possible mechanism of toxicity.
In vitro binding of monochloroacetic acid to cysteine sulfhydryl groups was determined by a colorimetric sulfhydryl analysis (Sedlak and Lindsay, 1968). Test substance (60 µM) was added to an aqueous solution of 60 µM cysteine-HCl.Monochloroacetic acid did not reduce significantly alkylate sulfhydryl groups of cysteine in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.