Registration Dossier
Registration Dossier
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EC number: 209-261-7 | CAS number: 563-76-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1997 - September 1997
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 2-bromopropionyl bromide
- EC Number:
- 209-261-7
- EC Name:
- 2-bromopropionyl bromide
- Cas Number:
- 563-76-8
- Molecular formula:
- C3H4Br2O
- IUPAC Name:
- 2-bromopropanoyl bromide
- Test material form:
- other: Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- arachis oil
- Concentration / amount:
- 2% & 1%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- arachis oil
- Concentration / amount:
- 2% & 1%
- No. of animals per dose:
- 5
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 1
- Group:
- test chemical
- Dose level:
- 2% v/v
- No. with + reactions:
- 5
- Total no. in group:
- 5
- Clinical observations:
- Erythema
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 1.0. Group: test group. Dose level: 2% v/v. No with. + reactions: 5.0. Total no. in groups: 5.0. Clinical observations: Erythema.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Extreme sensitiser to Guinea Pig skin.
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