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Diss Factsheets
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EC number: 204-690-6 | CAS number: 124-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
In a GLP compliant OECD TG 404 study, 500 mg pasty dodecylamines (Genamin 12R 100 D) were semi-occlusively applied to the shaved skin of six New Zealand White rabbits for 3 minutes exposure time. After that in 3 animals the treated skin sites were rinsed with water and in the other 3 animals with 3% acetic acid solution followed by water. Both treatments caused moderate to severe erythema and oedema. An epidermal necrosis was noted quickly in the animals rinsed with water (24 h), which appeared delayed on Day 4 (1 animal) and 5 (2 animals) when the skin was rinsed with a 3% acetic acid solution, then water. Recovery developed in all animals rinsed with acetic acid solution. The skin was normal but dry in 2 animals on Day 10 and in the last animal on Day 14, when rinsing was performed with a 3% acetic acid solution, when water. The recovery occurred only in 1 animal when rinsed with water on Day 14. An epidermal necrosis was still present in 2 out of 3 animals rinsed with water at the end of the observation period
No oedema was observed in the animals from Day 7, for both rinsing procedures
Under these experimental conditions, the test substance dodecylamines (Genamin 12R 100 D) was considered to be corrosive.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The most prominent toxic property of the primary alkylamines in general is their strong irritative / corrosive properties, which can be attributed to their basicity. In this respect, dodecylamines show good comparability which support the general use of read-across principles. There are no human data on acute local toxicity for dodecylamines nor for any of the other primary alkylamines considered a chemical category available. In animals, data from all primary alkylamines demonstrated a significant dermal irritative potential of this chemical category. Dodecylamines as well as C12 -18 -(even numbered)-alkylamines, tallow alkylamines and octadecenylamines were shown to be corrosive to rabbit skin, and, in consequence, not tested in rabbit eye. Hydrogenated tallow alkylamines and octadecylamines induced less severe effects in skin but caused severe eye irritation up to irreversible damage in the rabbit eye. For C12 -18 -(even numbered)-alkylamines, rat inhalation studies indicated irritative properties on the respiratory tract.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Dodecylamines fulfill the requirements for classification as Corrosive with the designation R35 - causes severe burns. Additionally, based on data from inhalation studies classification as Xi, R37 - irritating to respiratory system is indicated. Based on the dermal corrosive properties no testing for eye irritation was performed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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