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EC number: 212-305-8 | CAS number: 780-69-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity:
Oral (similar to OECD 401, no GLP, RL2), rat: LD50=2.83 ml/kg bw (corresponding to 2802 mg/kg bw) (Carpenter et al., 1974)
Dermal (similar to OECD 402, no GLP, RL2), rabbit: LD50=3.18 ml/kg bw (corresponding to 3014 mg/kg bw)
Inhalation: There are no acute inhalation data. In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as reliable data via the oral and dermal routes are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study report which meets basic scientific principles.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral dose toxicity was estimated by the gastric intubation of groups of five non-fasted, Carworth-Wistar male rats, four to five weeks of age and 90 to 120 grams in weight which have been reared in the laboratory own colony and maintained from time of weaning on Rockland rat diet, complete. The dosages were arranged in a logarithmic series differing by a factor of two. Whenever possible, the chemical was administered undiluted. Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range were estimated by the method of Thompson using the tables of Weil.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mellon Institute of Industrial Research, Pennsylvania, USA.
- Age at study initiation: 4-5 weeks.
- Weight at study initiation: 90-120 g (males)
- Diet : Maintained from time of weaning on Rockland rat diet, complete. - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- No details given
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 802 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- The very limited details given in the secondary source indicate the test substance to be of relatively low toxicity via the oral route.
Reference
The LD50 of 2.83 ml/kg bw (2.05 - 3.89 ml/kg bw) was converted using a specific density of 0.99 g/cm³.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 802 mg/kg bw
- Quality of whole database:
- The study predates OECD test guidelines and GLP. However, the protocol followed meets basic scientific principles.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP. The restrictions were that only 4 animals per dose were used and no analytical purity was reported.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- ; 4 animals per dose, analytical purity not reported
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- other: albino (no other details)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mellon Institute
- Age at study initiation: 3-5 months
- Weight at study initiation: No data
- Fasting period before study: No
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: Polyethylene sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Up to 16 mL/kg- Duration of exposure:
- 24 hours
- Doses:
- 2, 4, and 16 mL/kg
- No. of animals per sex per dose:
- 2 and 4 mL/kg: Four animals
16 mL/kg: Two animals - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No
- Other examinations performed: clinical signs, gross pathology - Statistics:
- No data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 014 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 920 - <= 5 128
- Remarks on result:
- other: dose given in ml/kg, converted using a specific density of 0.99 g/ml
- Mortality:
- No deaths in the 2 mL/kg bw group. In the 4 mL/kg bw group 3/4 animals died and both animals in the 16 mL/kg bw group died. In the highest dose group deaths were within one day of dosing. The three animals that died in the 4 mL/kg bw died on Days 2 and 4 following removal of dressings.
- Clinical signs:
- other: Two rabbits in the 4 mL/kg bw group were found prostate one day after dosing.
- Gross pathology:
- Congestion throughout the lungs and the abdominal viscera were observed. The liver and kidneys were mottled.
- Other findings:
- Erythema of the skin.
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- In an acute dermal toxicity study conducted using a protocol that was similar to OECD 402, but not in compliance with GLP (reliability score 2) the LD50 for the test substance triethoxy(phenyl)silane (CAS: 780-69-8). was 3.18 mL/kg bw in rabbits (equivalent to 3014 mg/kg bw based on a specific density of 0.99 g/mL).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 014 mg/kg bw
- Quality of whole database:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
Additional information
Acute oral toxicity:
In the key study for acute oral toxicity 5 male Carworth-Wistar rats were treated by oral gavage with the test substance (Carpenter et al., 1974; RL2). The LD 50 was found to be 2.83 ml/kg bw (2802 mg/kg bw based on a specific density of 0.99 g/cm³). No details about doses or mortality rates were given.
Acute inhalation toxicity:
No data.
Acute dermal toxicity:
In the key study for acute dermal toxicity 4 male Albino New Zealand rabbits were treated with 3.18 mL/kg bw for 24 h under occlusive conditions (Mellon Institute., 1972; RL2). The LD 50 was found to be 3.18 mL/kg bw (3014 mg/kg bw based on a specific density of 0.99 g/cm³). No details about doses or mortality rates were given.
Justification for classification or non-classification
The available data on acute toxicity of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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