Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 404-450-2 | CAS number: 118685-34-0 COBRATEC 435
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
One test animal was killed in extremis during the induction period. Signs of ill health inctuded noisy respiration, gasping, dark
eyes and lethargy. Autopsy revealed complete consolidation of anterior lung lobes with patchy consolidation of posterior lobes and pallor of liver: and kidneys. Death was not considered to be related to treatment.
One test animal was found dead prior to the challenge application. Tthe animal was autolysed and cannibalised and the cause of death could not be determined.
The bandage of a further one test animal came off prematurely. This animal was excluded from the final assessment.
The dermal reactions seen in six test animals were more marked than those seen in the controls.
In one further animal the dermal reactions were slightly more marked but not clearly different, from those seen in the controls.
The dermal response seen in the remaining ten animals was similar to the controls.
Migrated from Short description of key information:
In this study, Butyl benzotriazole - sodium salt 37% solution produced evidence of skin sensitisation (delayed contact hypersensitivity) in six test animals.
Justification for selection of skin sensitisation endpoint:
In this study, Butyl benzotriazole - sodium salt 37% solution produced evidence of skin sensitisation (delayed contact hypersensitivity) in six test animals. So, Butyl benzotriazole - sodium saIt 37% solution requires Iabelling the risk phrase with R43 "May cause sensitisation by skin contact" in accordance with the Directive 67/548/EEC and Hazardous Statement H317 "May cause an allergie skin reaction" in accordance with the regulation (EC) 1272/2008
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In this study, Butyl benzotriazole - sodium salt 37% solution produced evidence of skin sensitisation (delayed contact hypersensitivity) in six test animals. So, Butyl benzotriazole - sodium saIt 37% solution requires Iabelling the risk phrase with R43 "May cause sensitisation by skin contact" in accordance with the Directive 67/548/EEC and Hazardous Statement H317 "May cause an allergie skin reaction" in accordance with the regulation (EC) 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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