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Diss Factsheets
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EC number: 200-539-3 | CAS number: 62-53-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Aniline caused only slight topical reaction to the skin of rabbits in test for skin corrosion and irritation. An erythema grade 1 was observed in 6/6 rabbits after dermal application of 0.5 ml undiluted aniline. In contrast, during an acute dermal toxicity study dermal exposure to undiluted aniline for supposedly 24 h caused subdermal hemorrhages and severe erythema (Bio-Fax Industrial Bio-Test Laboratories, 1969). Application of undiluted aniline to the skin of 2 rabbits revealed slight erythema, which fully reversed within 8 days after exposure (BASF, 1972). Information from appropriate tests on skin irritation effects in humans is not available. In a study on dermal absoprtion Baranowska-Dutkiewicz (1982) exposed volunteers dermally to 0.25 ml undiluted aniline for 30 min at a relatively low concentration of approximately 0.01 ml/cm2. No dermal reaction in exposed volunteers has been reported.
For the assessment of serious eye damage and eye irritation two animal studies are available. Mean scores of ca. 53/110 for effects on cornea, iris and conjunctivae (moderate to severe effects) were reported within the first 3 days after instillation in one study (Bio-Fax Industrial Bio-Test Laboratories, 1969), whereas in the second study severe conjunctival erythema and edema were observed which did not reverse within a 8 day observation period. Furthermore, pannus formation was observed at the end of the expiration period (BASF, 1972).
Additional information on the eye irritation potential is available from acute inhalation studies in rats exposed head-only to aniline vapor (3mg/l/4h), where mild to severe corneal damage up to corneal clouding was observed until day 14 after exposure had ceased (DuPont de Nemours, 1982).
Justification for classification or non-classification
Appropriate testing of the potential effects of undiluted aniline on the skin showed no signs of corrosivity but only a slight edema. In rabbit eyes, severe effects on the cornea and severe conjunctival irritation were detected; eight days after instillation of the substance pannus formation was detected. According to the criteria in Annex VI to 67/548/EEC aniline is classified as "Xi, Irritant". According to the criteria in Annex I of the CLP regulation (EC) 1272/2008 aniline is classified as Category 1 for the hazard category irreversible effects on the eye/serious damage to eyes. Both classification for serious eye damage and non-classification for skin corrosion and irritation are in accordance with the entries in Annex VI to the CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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