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Diss Factsheets
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EC number: 202-615-1 | CAS number: 97-88-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: case study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Mixture of compounds, number of exposed subjects in each work group is very small. Health effects reported cannot clearly be attributed to exposure to BMA vapours.
Data source
Reference
- Reference Type:
- publication
- Title:
- Pulmonary Abnormalities and Serum Immunoglobulins in Facsimile Machine Repair Technicians|Exposed to Butyl methacrylate Fume.
- Author:
- Raymond LW
- Year:
- 1 996
- Bibliographic source:
- Chest 109: 1010 - 1018
Materials and methods
- Type of study / information:
- Type of experience: Human
- Endpoint addressed:
- respiratory sensitisation
- Principles of method if other than guideline:
- The study involves standard clinical and respiratory function tests as well as a chemical analysis fo the fumes
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Butyl methacrylate
- EC Number:
- 202-615-1
- EC Name:
- Butyl methacrylate
- Cas Number:
- 97-88-1
- Molecular formula:
- C8H14O2
- IUPAC Name:
- butyl methacrylate
- Details on test material:
- The emissions generated by the fax process studied were largely composed of deeply respirable BMA (isomer not specified, but more likely n-BMA) and other polymer decomposition products including C-4 fume and vapour phases, as well as some C-2 and C-3 compounds.
Constituent 1
Results and discussion
- Results:
- Exposure to polymer decomposition fumes also containing low levels of Butyl methacrylate (0.6 mg/m3 in air) released from coated fax paper was reported to be associated with respiratory symptoms during 1 to 2 years in seven fax machine repair technicians in New York.
Only few isolated symptoms in another group of workers in a larger room with fume levels from 0.14 to 0.40 mg/m³ in air.
Applicant's summary and conclusion
- Conclusions:
- In a group of seven fax machine repair technicians in New York a slight increase in respiratory symptoms and an increase in serum IgE was observed. The autors associated this with the exposure to fumes generated during machine operation. According to their results, the fumes (0.6 mg/m3 in air) consisted primarily of Butyl methacrylate (released from a BMA-containing polymer which coated the fax paper), but also other pyrolysis products.
- Executive summary:
In a group of seven fax machine repair technicians ina slight increase in respiratory symptoms and an increase in serum IgE was observed. The autors associated this with the exposure to fumes generated during machine operation. According to their results, the fumes (0.6 mg/m3 in air) consisted primarily of Butyl methacrylate (released from a BMA-containing polymer which coated the fax paper), but also other pyrolysis products.
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