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EC number: 206-058-5 | CAS number: 298-12-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Type of information:
- other: Literature data
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Literature data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Comparative biochemistry of the glyoxylate cycle
- Author:
- Cioni M. Pinzauti G., Vanni P.
- Year:
- 1 981
- Bibliographic source:
- Comp. Biochem. Physiol. 70B, 1-26
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 957
Materials and methods
- GLP compliance:
- not specified
- Type of medium:
- plant
Test material
- Reference substance name:
- Glyoxylic acid
- EC Number:
- 206-058-5
- EC Name:
- Glyoxylic acid
- Cas Number:
- 298-12-4
- Molecular formula:
- C2H2O3
- IUPAC Name:
- 2-oxoacetic acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Glyoxylic
acid is an important metabolite in the plants.
Glyoxylic acid-cycle is a shunt of the Krebs cycle in the plants and
some procaryotes cells.
It was studied by Kornberg and Krebs.
In a paper written in 1980, Cioni and al. described the enzymatic system
for the biotransformation of isocitrate in malate and succinate.
Isocitratelyase catalyses the aldolic cutting of isocitrate in succinate
and glyoxylate. Then, maltate-synthetase
transforms glyoxylate by adding COA.
Glyoxylate cycle is already a shunt of the Krebs'cycle, becoming from
and going to isocitrate.
Glyoxylic acid is found in number of plants having the C4 route,
essentially in germinative or growing phases in which lipids are
transformed in glucides.
In an other hand, enlightened plants use oxygen and excrete CO2
(photorespiration).
Glycolate, substrate of photorespiration, becomes from 1,5-diphospho-ribulose,
which is metabolized in
phosphoglycolate and then in glyoxylic acid by oxidation.
This reaction is catalyzed by an oxygenase, ribulose diphosphate-1,5
carboxylase.
Phosphoglycolate obtained by this metabolic route is hydrolyzed in
glycolate by a specific phosphatase. Then glycolate is oxidized, in the
peroxizomes, in glyoxylate by glycolate-oxydase. Glyoxylate is then
easily transformed in glycine.
The plants not having the C4 metabolisation route, loss 25 to 50 % of
their carbon due to the photorespiration, essentially in plants living
under temperate climates.
Applicant's summary and conclusion
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