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EC number: 200-467-2 | CAS number: 60-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from peer reviewed reference.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Reference Type:
- publication
- Title:
- Health effects assessment for ethyl ether
- Author:
- U.S. Environmental Protection Agency
- Year:
- 1 987
- Bibliographic source:
- Health effects assessment for ethyl ether, U.S. Environmental Protection Agency, 1987, EPA/600/8-88/039
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information available
- Principles of method if other than guideline:
- Study conducted by reputable testing laboratory for the U.S. EPA. Likely to be an early guideline study.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl ether
- EC Number:
- 200-467-2
- EC Name:
- Diethyl ether
- Cas Number:
- 60-29-7
- Molecular formula:
- C4H10O
- IUPAC Name:
- diethyl ether
- Details on test material:
- No information on the test material is available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- Daily gavage
Doses / concentrationsopen allclose all
- Dose / conc.:
- 500 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 2 000 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 3 500 mg/kg bw/day (actual dose received)
- No. of animals per sex per dose:
- 30 animals per sex per dose
- Control animals:
- yes, concurrent no treatment
Examinations
- Observations and examinations performed and frequency:
- Data collected from the study included body weight and organ weight changes, consumption of food, ophthalmological examinations, biochemical, clinical and gross morphology changes, and target organ histopathology.
BODY WEIGHT: Yes
- Time schedule for examinations: weekly - Sacrifice and pathology:
- An interim sacrifice was performed after 6 weeks of dosing. 10 rats per sex were used and the remaining allowed to continue until the end of the study.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- CLINICAL SIGNS AND MORTALITY
Mortality observed at 3500 mg/kg bw. 15/60 rats (6 male and 9 female) died.
Mortality observed at 2000 mg/kg bw. 4/60 rats (2 male and 2 female) died.
Light anesthesia was observed at 2000 mg/kg bw and especially so at 3500 mg/kg bw.
BODY WEIGHT AND WEIGHT GAIN
Body weight loss was observed at 3500 mg/kg bw in both sexes.
Only males showed significant loss at 2000 mg/kg bw.
FOOD CONSUMPTION
Decreased food intake was observed at 3500 mg/kg bw in males.
OPHTHALMOSCOPIC EXAMINATION
Ophthalmoscopic examination at sacrifice revealed retinal atrophy 2 male rats at 3500 mg/kg bw, 2 female rats at 2000 mg/kg bw, and in one female rat exposed at 500 mg/kg bw.
HAEMATOLOGY
At 3500 mg/kg bw exposure males had significant decreases in hemoglobin and hematocrit values and a slight increase in red blood cell count. Females showed no treatment related effects at 500 or 2000 mg/kg bw exposure.
CLINICAL CHEMISTRY
At 3500 mg/kg bw, SGPT and serum cholesterol levels were significantly increased in males, and SGOT levels were elevated in females. At 2000mg/kg bw transient increase of cholesterol in females was seen. Females showed no other treatment related effects at 500 or 2000 mg/kg bw exposure.
URINALYSIS
Females showed no treatment related effects at 500 or 2000 mg/kg bw exposure.
ORGAN WEIGHTS
The relative weights of brain, kidneys and testes/epididymides were increased in males at 3500 mg/kg bw, however, the significant reduction in body weight observed in this group makes interpretation difficult. Increase in relative liver weight was observed in females at 2000 mg/kg bw exposure. Females showed no other treatment related effects at 500 or 2000 mg/kg bw exposure.
GROSS PATHOLOGY
Necroscopy of 2000 and 3500 mg/kg bw exposed animals showed lung and liver discolouration and distention and discolouration of the stomach.
HISTOPATHOLOGY
No effects related to diethyl ether exposure were observed in target organ histopathology.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- other: significant body weigh depression
- Dose descriptor:
- LOAEL
- Effect level:
- 2 000 mg/kg bw/day (nominal)
- Sex:
- male
- Basis for effect level:
- other: significant body weigh depression
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.