Lead chromate molybdate sulfate red

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable study (20-hour exposure; only 8-day observation period)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was intact. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 48, 72 hours and until the end of the observation period. Findings were graded as described in OECD test guideline 404.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lead chromate molybdate sulfate red

EC Number:

235-759-9

EC Name:

Lead chromate molybdate sulfate red

Cas Number:

12656-85-8

Molecular formula:

Pb (Cr,S,Mo) O4

IUPAC Name:

tris(λ²-lead(2+)) dioxochromiumbis(olate) dioxomolybdenumbis(olate) sulfate

Details on test material:

- Name of test material (as cited in study report): molybdat red V 15243
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: containing 60% Pb; no additional data

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gaukler (1 male and 1 female animals)
- Age at study initiation: young adult animals
- Weight at study initiation: 3.0 kg (2.9 kg at the end) for the male animal, 3.6 kg (3.4 kg) for the female animal
- Diet (e.g. ad libitum): Ssniff
- Water: ad libitum

Test system

Type of coverage:

occlusive

Preparation of test site:

other: intact/shaved and abraded

Controls:

other: untreated skin of same animal

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): appr. 0.5 test substance wrapped in light wet cloth
- Concentration (if solution): not diluted

Duration of treatment / exposure:

20 hours

Observation period:

8 days

Number of animals:

1 male and 1 female animals

Details on study design:

TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: occlusive

REMOVAL OF TEST SUBSTANCE
no specified

SCORING SYSTEM: as described in OECD guideline 404 (readings after 24 hours, 48 hours, 72 hours and 8 days)

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 24-48-72 hour

Score:

0

Max. score:

4

Reversibility:

other: not applicable

Remarks on result:

other: only red to brawn coloration of the skin by test substance was observed. No adverse effects observed

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 24 hour

Score:

0

Max. score:

4

Reversibility:

other: not applicable

Irritant / corrosive response data:

The test substance has to be considered as considered as not irritating according to the EU and to GHS

Other effects:

The animals showed no erythema or edema formation after exposure to the test substance up to 20 h after removal of the patches A red discoloration of the skin was observed which was due to the intrinsic color of the test material. In case of the 20 h exposure, superficial brown patches were observed at the 24 h and 72 h reading which were reversible within the obeservation period of 8 days and do not represent a lokal skin reaction. Other toxic effects were not observed.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU