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EC number: 270-608-0 | CAS number: 68457-79-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study; well documented study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts
- EC Number:
- 270-608-0
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts
- Cas Number:
- 68457-79-4
- Molecular formula:
- {[(iso-C4H9O)0.64(C5H11O)0.36]PS2}2Zn - neutral, {[(iso-C4H9O)0.64(C5H11O)0.36]PS2}6Zn4O - basic
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Research Products Inc., Denver PA
- Weight at study initiation: 2.59- 2.64 kg males and 2.65- 2.97 kg females.
- Housing: Individual suspended stainless steel cages.
- Diet (e.g. ad libitum): ad libitum.
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 22 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.3-21.6
- Humidity (%):40-60%.
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark.
IN-LIFE DATES: 5 August 1986 – 12 August 1986
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
The test material was dosed (0.5ml/site) as received. - Duration of treatment / exposure:
- The test substance was administered once per site and remained in contact with the skin for 4 hours followed by removal with disposable paper towels moistened with light, white mineral oil.
- Observation period:
- The skin was examined and graded for dermal reaction at 60 minutes, 24, 48 , and 72 h following patch removal and on Day 7.
- Number of animals:
- 3 males and 3 females
- Details on study design:
- TEST SITE
On the day prior to dosing, the hair was removed from the shoulder region tot eh lumbar region with electric clipper. Each animal received 0.5 ml dose to two separate sites (right dorsal thoracic and left dorsal thoracic) under a gauze patch which was secured with tape. The patch was loosely held in contact with the skin by means of a semi-occlusive dressing for the duration of the exposure period. After approximately 4 hours of exposure, the dressing and gauze patch were removed. Residual test material on the right dorsal thoracic dose site was removed with paper towels saturated in distilled water; residual test material on the left dorsal thoracic dose site was removed with paper towels saturated in white oil.
SCORING SYSTEM: Dermal Irritation was graded in accordance with the Draize method of scoring.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: sites wiped with water
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.8
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: sites wiped with water
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: sites wiped with oil
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: sites wiped with oil
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 4.4
- Max. score:
- 8
- Reversibility:
- other: not applicable
- Remarks on result:
- other: sites wiped with water
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 4
- Max. score:
- 8
- Reversibility:
- other: not applicable
- Remarks on result:
- other: sites wiped with oil
- Irritant / corrosive response data:
- At the 60 minute observation, all animals exhibited very slight to well-defined erythema at both dose sites. Edema at this time ranged from very slight to slight for four animals at the right dose site (test article removed with distilled water), while three animals exhibited very slight edema at the left dose site (test article removed with white oil). Erythema and edema scores increased at the 24, 48, and 72 hour observations, with the right dose site exhibiting slightly higher scores than the left dose site. Irritation decreased at both dose sites on Day 7 when all animals displayed very slight to well defined erythema and five animals showed very slight to slight edema. However scores at the right dose site were again slightly higher than the left dose sight
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of this study, the test substance would be classified as a Category 2 in accordance with the classification system of GHS
- Executive summary:
The primary dermal irritation potential of the test material was evaluated in this study with New Zealand White rabbits. The test material was administered to two separate sites (right dorsal thoracic and left dorsal thoracic). At each single site, 0.5 ml doses of undiluted test material were applied under gauze patch which was secured with tape. The patch was loosely held in contact with the skin by means of a semi-occlusive dressing for a four hour exposure period. At completion of exposure the dressing and gauze were removed and the right dorsal thoracic site was removed with paper towels moistened with distilled water; residual test material on the left dorsal thoracic dose site was removed with paper towels saturate in white oil. Application sites were evaluated in accordance with the method of Draize at approximately 60 minutes, 24, 48, and 72 hours and Day 7 after patch removal.
ThePrimary Irritation Index was calculated to be 4.42 for sites wiped with distilled water.
ThePrimary Irritation Index was calculated to be 4.0 for sites wiped with white oil.
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