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EC number: 239-879-2 | CAS number: 15782-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see the category read-across justification in the category object.
- Transformation products:
- no
- Key result
- Remarks on result:
- other: not hydrolysed at pH 4, 7 and 9
Reference
Description of key information
According to structural properties and the results of a hydrolysis study using a structural analogue, hydrolysis is not expected/probable.
Key value for chemical safety assessment
Additional information
In a guideline study conducted in compliance with OECD 111, the hydrolysis of a category member (CAS 5281-04-9) as a function of pH was tested. No hydrolysis at pH 4, 7 and 9 was determined (MITI, Japan 1994). Furthermore, a supporting preliminary study according to OECD 111 for CAS 73612-29-0 is available (RCC Ltd. 2003) showing that the test substance is hydrolytically stable.
Waiving argument:
According to literature data of Harris (1990), Kollig et al. (1993) and Boethling & Mackay (2000) hydrolysis of the substance is not expected.
Justification:
Substance has half-lifes at 25°C of above 1 year
This is the criterion for sufficiently stable substances given in OECD TG 111 indicating that no further hydrolysis testing is required (OECD 2004). Substances with half-lifes at pH 4, 7 and 9 and 25°C definitely above one year are for example NHFG (no hydrolysable functional groups)- and NLFG (no labile functional groups)- compounds according to Kollig et al. 1993 and Wolfe and Jeffers 2000. Important categories of organic substances fulfilling these criteria are listed in table 1. The rationale of this waiving argument is that abiotic hydrolysis is at best very slow under environmentally relevant conditions and thus of minor importance.
As no significant further functional group than the ones listed in table 1 have been identified in the structure(s) of the whole category, hydrolysis is not expecdted.
Table 1: Organic chemicals with half-lifes at pH 4 to 9 and 25°C above one year.
Organic substance category |
Source |
Alkanes |
Harris 1990 |
Alkenes |
Harris 1990 |
Alkynes |
Harris 1990 |
Vinyl chloridea |
Kollig et al. 1993, Mabey and Mill, 1978 |
Benzenes/Biphenyls |
Harris 1990 |
Xylenes |
Kollig et al. 1993, Wolfe and Jeffers 2000 |
Polycyclic aromatic hydrocarbonsb |
Harris 1990, Kollig et al. 1993 |
Halogenated aromatics/PCBs |
Harris 1990, Mabey and Mill, 1978 |
Aromatic nitro compounds |
Harris 1990, Kollig et al. 1993 |
Amines |
Kollig et al. 1993 |
Aromatic amines |
Harris 1990, Wolfe and Jeffers 2000 |
Alcohols |
Harris 1990, Kollig et al. 1993 |
Phenols |
Harris 1990 |
Glycols |
Harris 1990 |
Nitriles |
Mabey and Mill 1978 |
Ethers |
Harris 1990, Kollig et al. 1993 |
Aldehydes |
Harris 1990 |
Ketones |
Harris 1990 |
Carboxylic acids |
Harris 1990, Wolfe and Jeffers 2000 |
Sulfonic acids |
Harris 1990 |
aand higher chlorinated derivatives.
bHomo- and heterocyclic species.
References
Boethling RS, Mackay D (2000) Handbook of property estimation methods for chemicals: Environmental health and sciences. Chapter 13. Hydrolysis. CRC Press LLC, Boca Raton, Florida.
Harris JC (1990) Rate of hydrolysis. In Lyman WJ, Reehl WF, Rosenblatt, DH (eds.) Handbook of chemical property estimation methods. 3rd edn. ACS Washington.
Kollig HP, Ellington JJ, Karickhoff SW, Kitches BE, Long JM, Weber EJ, Wolfe NL (1993) Environmental fate constants for organic chemicals under consideration for EPA’s
hazardous waste identification projects. EPA/600/R-93/132.
Mabey W, Mill T. 1978. Critical review of hydrolysis of organic compounds in water under environmental conditions. J Phys Chem Ref Data:383-415.
OECD. 2004. OECD Guideline for the testing of chemicals. No 111. Hydrolysis as a function of pH.
Wolfe NL, Jeffers, PM. 2000. Hydrolysis. In Boethling RS, Mackay D (eds) Handbook of property estimation methods for chemicals: Environmental and health sciences. CRC Press, LLC, Boca Raton, Florida.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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