3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

other:

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

Isophorondiisocyanat / Chemikalien und Kontaktallergie - Eine bewertende Zusammenstellung

Author:

Kayser D and Schlede E (Eds.)

Year:

2001

Bibliographic source:

Urban & Vogel Medien und Medizin Verlagsgesellschaft mbH & Co. KG., München 17+2 pp

Materials and methods

Study type:

human medical data

Endpoint addressed:

skin sensitisation

Principles of method if other than guideline:

data collection, published as a loose-leaf-book

Method

Type of population:

occupational

Ethical approval:

not applicable

Details on study design:

expert judgement on the potency ranking of chemicals with contact allergenic properties

Results and discussion

Results:

Based on experience in humans and animals the substance is ranked as a category B sensitiser. There are indications of cross-reactivity with other diisocyanates. Diisocyanates are known to cause inhalation allergies (Deutsche Forschungsgemeinschaft, 1995).

Applicant's summary and conclusion

Conclusions:

The test item was ranked as a Category B sensitizer.

Executive summary:

The test item was ranked as a Category B sensitizer. Substances with a solid-based indication of a contact allergenic potential and substances with the capacity of cross reactions were listed in Category B.