Registration Dossier
Registration Dossier
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EC number: 202-777-3 | CAS number: 99-66-1
Explosiveness
Administrative data
- Endpoint:
- explosive properties of explosives
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: regulation EG No 1272/2008 by differential scanning calorimetry
- GLP compliance:
- no
Test material
- Reference substance name:
- Valproic acid
- IUPAC Name:
- Valproic acid
- Details on test material:
- - Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.
Constituent 1
Results and discussion
Small-scale preliminary tests
- Parameter:
- other: decomposition energy (J/g)
- Remarks on result:
- other: Since the absolute value of the decomposition energy was below 500 J/g the substance can be classified as non-explosive.
- Remarks:
- No further testing is required.
Any other information on results incl. tables
The explosive properties of 2-Propylvaleric acid were determined according to regulation EG No 1272/2008 by differential scanning calorimetry. Samples of the test substance were filled into gold plated high pressure crucibles and heated to 500 °C in a differential scanning calorimeter. The test was performed twice. The onset temperature of the exothermal decomposition reaction was 𝑻onset = 162 °C.
with a decomposition energy of Δ𝑼 = −19 ± 1 J/g and 𝑻onset = 392 °C with a decomposition energy of Δ𝑼 = −84 ± 4 J/g. Since the absolute value of the decomposition energy was below 500 J/g the substance can be classified as non-explosive. No further testing is required.
Applicant's summary and conclusion
- Interpretation of results:
- other: non explosive
- Conclusions:
- Valproic acid is considered non explosive.
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