Registration Dossier
Registration Dossier
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EC number: 200-836-8 | CAS number: 75-07-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1946
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Further studies on sensory response to certain industrial solvent vapors
- Author:
- Leslie Silverman
- Year:
- 1 946
- Bibliographic source:
- Journal of industrial hygiene and toxicology, 28, p. 262
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- eye irritation by vapor exposure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Acetaldehyde
- EC Number:
- 200-836-8
- EC Name:
- Acetaldehyde
- Cas Number:
- 75-07-0
- Molecular formula:
- C2H4O
- IUPAC Name:
- acetaldehyde
- Details on test material:
- no details available
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- 12 subjects of both sexes
- Ethical approval:
- not specified
- Route of exposure:
- other: gas
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- Exposure to 25, 50 and 200 ppm for 15 min
- Examinations:
- eyes, sensory organs
- Medical treatment:
- -
Results and discussion
- Clinical signs:
- reddened eyelids and bloodshot eyes
- Results of examinations:
- -
- Effectivity of medical treatment:
- -
- Outcome of incidence:
- -
Applicant's summary and conclusion
- Conclusions:
- Acetaldehyde is irritating to the eyes of human.
- Executive summary:
Acetaldehyde was investigated for sensory effects on humans. At 200 ppm bloodshot eyes and reddened eyelids were reported. It can be assumed that direct contact of acetaldehyde with the human eye will have similar or more severe effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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