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EC number: 201-187-3 | CAS number: 79-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: no data available
Hydrolysis product methanol: with high probability acutely not harmful to aquatic invertebrates
Hydrolysis product: HCl: Acutely very toxic for aquatic invertebrates (pH dependent).
Key value for chemical safety assessment
Additional information
No data for the parent methyl chloroformate (CAS 79-22-1) are available. However, the parent compound rapidly hydrolyses in contact with water and forms methanol (CAS 67-56-1), HCl (CAS 7647-01-0) and CO2 (CAS 124 -38 -9). Therefore, the acute toxicity to aquatic invertebrates will be assessed based on the information available for the hydrolysis products methanol and HCl.
Parent compound methyl chloroformate:
No data available.
Hydrolysis product methanol:
The acute toxicity of the hydrolysis product methanol to aquatic invertebrates was tested according to German Industrial Standards DIN 38412-11 using Daphnia magna as test organism (Kuehn, 1989). The exposure was static. Analytical monitoring was not performed. The 48-h EC50 was determined to be > 10000 mg/L (nom.).
This result is supported by a test according to OECD 202 published by Dom et al. (2012). The acute toxicity of the hydrolysis product methanol to aquatic invertebrates was tested using D. magna as test organism under semi-static exposure. The 96-h EC50 was found to be 18260 mg/L, based on nominal test concentrations.
Toxicity values well above 10000 mg/L reported also for Daphnia magna in another study supports this finding: 48-h EC50 = 22200 mg/L (nom.; Rossini and Ronco 1996).
Aditionally short-term toxicity data are available from tests conducted with a marine organism: Mytilus edulis, 96 -h LC50 = 15900 mg/L (Helmstetter et al. 1996).
In conclusion, it can be considered, that methanol is with high probability acutely not harmful to aquatic invertebrates.
Hydrolysis product HCl:
HCl was tested in an acute toxicity test according to OECD 202 with D. magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; MITI, 1999; peer reviewed data: OECD SIDS, 2002). Therefore, based on the available experimental data the hydrolysis product HCl is considered to be acutely very toxic for aquatic invertebrates (pH dependent). These data have not been taken into consideration to evaluate aquatic toxicity as observed effects are caused by a pH-shift in the test medium.
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