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EC number: 253-760-2 | CAS number: 38051-10-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 July - 2 September 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Justification for type of information:
- Read-across of data measured for the structurally related substances TCPP and TDCP could be considered to be justified. Furthermore, based on the absence of effects in the short-term test in the earthworms, it could be assumed that earthworm would not be the most sensitive species following longer-term exposure, although chronic effects of the substance on the earthworm cannot be ruled out.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- Qualifier:
- according to guideline
- Guideline:
- ISO 14238
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Nitrate concentration start experiment (Day 0): 28 mg/kg
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- AMENDMENT OF SOIL
- Type of organic substrate: sandy loam (Landwirtschaftliche Untersuchungs- und forschungsanstalt Speyer, Germany)
APPLICATION OF TEST SUBSTANCE TO SOIL
- Method: silica gel containing test substance and 4.3 mL deionized water is added to 50 grams of soil
VEHICLE:
- Chemical name of vehicle: dichloromethane
- Evaporation of vehicle before use: yes (3 hours in ventilated hood) - Test organisms (inoculum):
- other: Nitrifying microorganisms in sandy loam soil
- Total exposure duration:
- 28 d
- Test temperature:
- 18 - 22 degree C
- Moisture:
- Water added to soil to approximately 45% of the maximum water holding capacity (pF about 2.5)
- Details on test conditions:
- TEST SYSTEM
- Test container: 0.5L serum flasks (glass)
- Amount of soil: 50 g
- No. of replicates: 3
SOURCE AND PROPERTIES OF SUBSTRATE
- Standard soil type: sandy loam
- pH (in water): 6.1 - 6.5
- Maximum water holding capacity: 35.2 +/- 3.3 (g/100g)
- Cation exchange capacity (mval/100g): 4 - 14
- Storage: 2 months in refrigerator in polyethylene bags
- Initial microbial biomass as % of total organic C:
DETAILS OF PREINCUBATION OF SOIL
Preconditioned by incubating for 7 days at 20 degree C at 10% of its water holding capacity
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Nitrate concentration in soil on day 0 and day 28, activity (mg NO3/kg day), inhibition (%) - Nominal and measured concentrations:
- Nominal concentrations test substance: 0, 2, 4, 8, 16, 32, 64 and 128 mg/kg
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- > 128 mg/kg soil dw
- Conc. based on:
- other: calculated from measured conc. total phosphorous in stock solution
- Basis for effect:
- nitrate formation rate
- Details on results:
- Nitrate formation in soil is not inhibited up to the highest tested concentration of 128 mg/kg soil. The activity of the microorgaisms in soil even increased in the presence of the test substance at the higher concentrations (nitrate concentration in control 53 mg/kg; 54-84 mg/kg in treated soils).
- Validity criteria fulfilled:
- yes
- Conclusions:
- No inhibition of nitrate formation up to a test concentration of 128 mg/kg soil was observed. Nitrate formation increased where higher concentrations of the test substance were present in the soil (dose-dependent).
- Executive summary:
In a 28 -day toxicity study, soil microorganisms were exposed to 2,2 -bis(chloromethyl)trimethylene bis(bis(2 -chloroethyl)phosphate) at 0, 2, 4, 8, 16, 32, 64 and 128 mg/kg soil. There was no inhibition of nitrate formation up to the highest tested concentration of 128 mg/kg soil. Nitrate formation even increased at higher test concentrations. The test substance is considered to be non-toxic to soil microorganisms up to a concentration of 128 mg/kg soil.
28-day NOEC > 128 mg/kg soil
This study is classified as reliable without restrictions and satisfies the guideline requirements for a nitrogen transformation inhibtion test, according to OECD Guideline No.216 (2000).
Reference
Description of key information
NOEC of ≥128 mg/kg soil
Key value for chemical safety assessment
Additional information
Inhibition of soil nitrogen transformation by soil micro-organisms has been examined in a study with tris[2-chloro-1-(chloromethyl)ethyl] phosphate (TDCP). No toxicity data on soil micro-organisms is available for 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate].
Read-across
Read across from TDCP is considered justified on the grounds that:
- TDCP and 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] share similar soil adsorption properties (see section 5.4.1). The bioavailability of the substances is therefore expected to be comparable.
- Reliable toxicity data suggest a consistent low order of acute toxicity for 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] and TDCP to mico-organisms present in waste-water treatment plants (IC50 > 1000 mg/L, IC50 > 10000 mg/L resp, not further reported here)
- Reliable effects data are available for a range of other freshwater and terrestrial organisms for 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] and TDCP. In no instance does 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] cause an effects at a lower concentration than TDCP. Therefore it is not anticipated that read-across of this result could result in an overly favourable conclusionin respect of 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate].
Toxicity to micro-organisms
In a 28 -day soil-microorganism nitrogen transformation test according to OECD 216 with TDCP a NOEC of ≥128 mg/kg soil (no inhibition at the highest concentration tested) was determined in the test.
References:
- European Union Risk Assessment Report "2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate]" (V6), CAS 38051-10-4, May 2008
- European Union Risk Assessment Report“tris[2-chloro-1-(chloromethyl)ethyl] phosphate” (TDCP), CAS 13674-87-8, May 2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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