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EC number: 244-742-5 | CAS number: 22036-77-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3.8.1982-17.8.1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a protocol similar to the current guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- EDTMP-xNa
- IUPAC Name:
- EDTMP-xNa
- Reference substance name:
- [ethylenebis[nitrilobis(methylene)]]tetrakisphosphonic acid, sodium salt
- EC Number:
- 244-742-5
- EC Name:
- [ethylenebis[nitrilobis(methylene)]]tetrakisphosphonic acid, sodium salt
- Cas Number:
- 22036-77-7
- Molecular formula:
- C6H20N2O12P4.xNa
- IUPAC Name:
- x sodium (8-x) hydrogen {ethane-1,2-diylbis[nitrilobis(methylene)]}tetrakis(phosphonate)
- Details on test material:
- - Name of test material (as cited in study report):Briquest 422-25S (ethylene diamine tetra methylene phosphonic acid-sodium salt)
- Physical state: straw coloured liquid
- Storage condition of test material: in a screw top plastic container, at ambient temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: A. Tuck & Sons Ltd., Battlesbridge, Essex.
- Age at study initiation: ca. 6-8 weeks
- Weight at study initiation: 216-255g
- Fasting period before study: 210-232g
- Housing: individually housed during the 24 hour exposure period, and in groups of 5 for the remainder of the study in polypropylene cages with sawdust beding
- Diet: standard laboratory diet, ad libitum
- Water: ad libitum
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 65-75%RH
- Air changes (per hr): ca.15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk of the rat
- Type of wrap if used: elastic adhesive bandage, backed with aluminium foil
REMOVAL OF TEST SUBSTANCE
- Washing (if done): once the bandage and foil were removed the skin and surrounding hair were sponged thoroughly with warm water, rinsed and dried using absorbent paper.
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 10 ml/kg - Duration of exposure:
- 24h
- Doses:
- 10 ml/kg
- No. of animals per sex per dose:
- 5M, 5F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed 0.5, 1, 2, 3, 4 and 5 hours following dosing. On subsequent days, the animals were observed at least once. Mortalities and evident toxicity were recorded at each observation. Individual body weights were recorded on days 0, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: The macroscopic appearance of abnormal organs was recorded. - Statistics:
- Using the mortality data, an assessment of the acute percutaneous median lethal dose of the test material was made.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 250 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: calculated from reported value
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: No signs of reaction to treatment were observed in any animal throughout the observation period.
- Gross pathology:
- Autopsy of animals killed on day 14 did not reveal any macroscopic abnormalities.
- Other findings:
- None reported.
Any other information on results incl. tables
The test material Briquest 422 - 25S comprises of 25% active acid. Because the results are reported in ml/kg the specific gravity (1.3 -1.36) was used to calculate the LD50 in terms of active acid in mg/kg.
10/4=2.5 ml/kg
2.5 ml/kg x 1.3 g/ml = 3250mg/kg active acid
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute dermal LD50 value of >10 ml/kg was reported in a study conducted according to a protocol similar to current guideline and in compliance with GLP. The specific gravity was used to calculate the LD50 value in units comparable to current CLP, which derived the value of >3250 mg/kg.
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