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EC number: 201-853-3 | CAS number: 88-72-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other: EU Risk Assessment
- Rationale for reliability incl. deficiencies:
- other: no reliability is given as this is a summary entry for the EU RAR
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- European Union Risk Assessment Report - 2-Nitrotoluene
- Author:
- European Commission - European Chemicals Bureau
- Year:
- 2 008
- Bibliographic source:
- Office for Official Publications of the European Communities
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
- Reference Type:
- publication
- Title:
- Toxic Hazards Evaluation of Five Atmospheric Pollutants from Army Ammunition Plants
- Author:
- Kinkead ER, MacEwen JD, Haun CC, Vernot EH and Dacre JC
- Year:
- 1 977
- Bibliographic source:
- National Technical Information Service. NTIS AD-A043 957
- Reference Type:
- other company data
- Title:
- Unnamed
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-nitrotoluene
- EC Number:
- 201-853-3
- EC Name:
- 2-nitrotoluene
- Cas Number:
- 88-72-2
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- 1-methyl-2-nitrobenzene
Constituent 1
Results and discussion
Any other information on results incl. tables
EU Risk Assessment (2008):
The acute dermal toxicity of 2-nitrotoluene has been investigated in two studies in rabbits and in one rat study. The studies were reported over the period 1972-77, pre-guideline performed and GLP non compliant. However, they appear to be broadly similar to modern test guidelines although the purity of the test substance was not reported.
Rats
A limit test was carried out at one dose level, 5000 mg/kgb.w. in a group of 6 female SPF Wistar rats. The test substance was applied undiluted on the clipped back for 24 hours, covered by a plaster and then washed, not observing either mortality or toxicity within 14-day observation period (Hollander and Weigand, 1975).
Rabbits
A limit test was carried out at one dose level, 20000 mg/kgb.w. in a group of 3 female albino rabbits. The test substance was applied undiluted to the clipped back and was kept in place by gauze patches, latex rubber, dental dam and elastic adhesive tape for 24 hours, and then removed. All rabbits were symptom free and gained weight normally during the subsequent 14-day observation period.
2-nitrotoluene was applied to the intact clipped on the dorsal skin of 6 male albino rabbits at a dose level of 200 mg/kgb.w. The rabbits´ trunks were then wrapped with a layer of Saran®
Wrap, stretch gauze bandage and elastic adhesive tape. After 24 hours, the wrappings were removed and the skin washed and dried. The animals were fitted with plastic collars to prevent ingestion of any residue and were observed for a further 48 hours. There were not mortality and clinical signs (McDonnell and Reinhardt, 1972).
Table 1: Summary of acute dermal toxicity of 2-nitrotoluene in experimental animals
Species | Dosage | LD 50 (mg/kgb.w.) | Comments | References |
Rat, SPFWistar (female) 6rats/group
| 5000 mg/kg bw (24 h) | >5000 mg/kg bw
| Purity not given Limit test
| Hollander and Weigand (1975)
|
Rabbit,albino(male) 6rabbits/group
| 200 mg/kg bw (24 h)
| >200 mg/kg bw
| Purity not given
| McDonnell and Reinhardt (1972)
|
Rabbit, albino New Zealand (female) 3 rabbits/group
| 20000 mg/kg bw.(24 h)
| >20000 mg/kg bw
| Purity not given Limit test
| Kinkead et al. (1977)
|
Applicant's summary and conclusion
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