Registration Dossier
Registration Dossier
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EC number: 201-788-0 | CAS number: 87-99-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- The scientific validity of the (Q)SAR model has been established in accordance with the OECD Principles for (Q)SAR Model Validation.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- OECD Toolbox v3.1
Estimation by TIMES: Skin sensitization v. 16.19 with autoxidation
Toolbox prediction report is attached in IUCLID - GLP compliance:
- no
- Justification for non-LLNA method:
- QSAR prediction
Test material
- Reference substance name:
- Xylitol
- EC Number:
- 201-788-0
- EC Name:
- Xylitol
- Cas Number:
- 87-99-0
- Molecular formula:
- C5H12O5
- IUPAC Name:
- (2R,3r,4S)-pentane-1,2,3,4,5-pentol
- Details on test material:
- SMILES:C(O)(C(O)C(O)CO)CO
Constituent 1
Results and discussion
In vivo (non-LLNA)
Results
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- based on QSAR results
Any other information on results incl. tables
Results by QSAR utilising Times within the OECD Toolbox were negative indicating that the substance is not sensitising.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Results by QSAR utilising Times within the OECD Toolbox were negative indicating that the substance is not sensitising.
- Executive summary:
Results by QSAR utilising Times within the OECD Toolbox were negative indicating that the substance is not sensitising. The target substance falls within applicability domain of the prediction. Supporting documentation is provided in the attached prediction report.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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