Registration Dossier
Registration Dossier
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EC number: 204-706-1 | CAS number: 124-63-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mouse tail method
- GLP compliance:
- no
Test material
- Reference substance name:
- Methanesulphonyl chloride
- EC Number:
- 204-706-1
- EC Name:
- Methanesulphonyl chloride
- Cas Number:
- 124-63-0
- Molecular formula:
- CH3ClO2S
- IUPAC Name:
- methanesulfonyl chloride
- Details on test material:
- Test article name : Methane sulfonyl chloride
Cas n°: 124-63-0
Origin: Pennwalt Corporation
Batch no. : no data
Purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- One hour
- Observation period:
- 2 days
- Number of animals:
- 4
- Details on study design:
- The tails of four anesthetized mice were immersed in the sample to a depth of 4 cm. one hour later the tissue reaction was terminated by plunging the appendages into a saturated solution of sodium bicarbonate for a period of 30 seconds; each tail was then rinsed with water and blotted dry.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Necrosis
- Time point:
- other: 1 hour
- Reversibility:
- not reversible
- Remarks on result:
- other: the tail of each animal was white (not pink) when exposure was terminated and the appendage fell off in a day or two
- Irritant / corrosive response data:
- the tail of each animal was white (not pink) when exposure was terminated and the appendage fell off in a day or two.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Executive summary:
A limited study performed with the “mouse tail method” indicate that methanesulfonyl chloride is corrosive.
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