Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 913-888-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on reliable studies with ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate for acute oral and dermal
exposure to rats, the oral LD50 is >2000 mg/kg bw and the dermal LD50 is >5000 mg/kg bw.
For liquid form of the reaction mass, since the vapour pressure is low, inhalation exposure is not expected.
For solid form of the reaction mass, since the aerodynamic diameter is high, inhalation exposure to this solid form is not expected. Moreover, a
reliable acute toxicity inhalation study with diammonium hydrogenorthophosphate shows an LC50 is > 5 mg/L.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Oral
For acute oral toxicity, ammonium dihydrogenorthophosphate showed in an OECD 425 guideline study no mortality and no toxicity to rats up to 2000 mg/kg bw. Therefore the LD50 was determined to be >2000 mg/kg bw. For acute oral toxicity, diammonium hydrogenorthophosphate showed in an OECD 425 guideline study no mortality and no toxicity to rats up to 2000 mg/kg bw. Therefore the LD50 was determined to be >2000 mg/kg bw.
Dermal
For acute dermal toxicity, ammonium dihydrogenorthophosphate showed in an OECD 402 guideline study no mortality and no toxicity to rats up to 5000 mg/kg bw. Therefore the LD50 was determined to be >5000 mg/kg bw. For acute dermal toxicity, diammonium hydrogenorthophosphate showed in an OECD 402 guideline study no mortality and no toxicity to rats up to 5000 mg/kg bw. Therefore the LD50 was determined to be >5000 mg/kg bw.
Inhalation
Liquid form: since exposure by inhalation is not expected (low vapour pressure, assimilated to vapour pressure of water), an acute toxicity data by inhalation is not mandatory.
Solid form: the aerodynamic diameter of the solid form of the reaction mass is high. Therefore, inhalation exposure to this type of reaction mass is not expected. Moreover, a reliable study with diammonium hydrogenorthophosphate particles was available, showing in an OECD 403, EC B.2 and EPA guideline study no mortality and no toxicity to rats up to 5 mg/L. Therefore, the LC50 was determined to be >5 mg/L for diammonium hydrogenorthophosphate particles.
Justification for classification or non-classification
Based on the data available for the two components, the reaction mass of ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate does not have to be classified according to the Directive 67/548/EC and the CLP Regulation for acute oral and dermal toxicity.
For inhalation, based on the available study performed on diammonium hydrogenorthophosphate particles in which a LC50 >5 mg/L was calculated, the solid form of the reaction mass is not classified for inhalation toxicity according to the Directive 67/548/EC and the CLP Regulation. Moreover, since the aerodynamic diameter of the solid form of the reaction mass is high, inhalation exposure to this type of reaction mass is not expected.
For liquid form, since the vapour pressure is low, inhalation exposure is not expected.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.