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EC number: 700-361-0 | CAS number: 361442-00-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 December 2004 to 23 May 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted in 2005 according to EU and OECD Method and in accordance with GLP. The study material is well characterized.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- other: differential scanning calorimetry (DSC)
Test material
- Reference substance name:
- (2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid
- EC Number:
- 700-361-0
- Cas Number:
- 361442-00-4
- Molecular formula:
- C17H27NO5
- IUPAC Name:
- (2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid
- Reference substance name:
- 1-Hydroxyadamantanyl-3-(S)-Boc-glycine
- IUPAC Name:
- 1-Hydroxyadamantanyl-3-(S)-Boc-glycine
- Details on test material:
- Off-white powder; stored at room temperature; received at testing laboratory on 06-10-2004.
Constituent 1
Constituent 2
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- 180.2 °C
- Decomposition:
- yes
- Decomp. temp.:
- ca. 380 °C
Any other information on results incl. tables
Test 1
A melting endotherm was observed with a peak temperature of 180.0°C. A second endotherm was observed, due to the boiling point, with a peak temperature of 303.3°C. An unsteady baseline was subsequently observed, starting at ca. 380°C, indicative of
decomposition of residue.
Test 2
A melting endotherm was observed with a peak temperature of 180.3°C. A second endotherm was observed, due to the boiling point, with a peak temperature of 305.8°C.
Applicant's summary and conclusion
- Conclusions:
- The thermal behaviour of BMS 528233-01 was assessed by Differential Scanning Calorimetry. A melting endotherm was observed with a peak temperature of 180.2°C. A second endotherm was observed, due to the boiling point, with a peak temperature of 304.6°C. An unsteady baseline was also observed, starting at ca. 380°C, indicative of decomposition of residue.
- Executive summary:
The melting point is defined as the temperature at which the phase transition from solid to liquid state takes place. Similarly, the boiling point is defined as the temperature at which the saturated vapour pressure of a liquid is the same as the standard (atmospheric)
pressure.
Both the melting and boiling point of the test substance were determined by differential scanning calorimetry (DSC). This is a technique in which a sample and a thermally inert reference material are subjected to a programmed temperature increase that is linearly ramped with time. The sample or reference is heated to maintain zero temperature difference, and the energy is plotted as a function of the programmed temperature. This provides a direct calorimetric measure of the energy of the reaction or transition. For
example, if substance and empty reference pans are heated over the test substance's solid to liquid-phase transition temperature, the energy required to melt the test substance can be determined along with the actual melting temperature. The boiling or decomposition
parameters can similarly be determined.
A melting endotherm was observed with a peak at 180.2°C, followed by a probable boiling endotherm with a peak temperature of 304.6°C
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